WAVE1 (Phospho Tyr125) Cell-Based Colorimetric ELISA Kit
-KA1349C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
WAVE1 Rabbit pAb
YT4897
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Primary Antibodies
WAVE1 (Phospho Tyr125) Rabbit pAb
YP0680
预览→
ELISA Kits
Total WAVE1 Cell-Based Colorimetric ELISA Kit
KA4323C
预览→
ELISA Kits
WAVE1 (Phospho Tyr125) Cell-Based Colorimetric ELISA Kit
KA1349C
预览→
抗原&靶点信息
基因名称:
WASF1
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别名:
Wiskott-Aldrich syndrome protein family member 1 ;
WASP family protein member 1 ;
Protein WAVE-1 ;
Verprolin homology domain-containing protein 1 ;
WASP family protein member 1 ;
Protein WAVE-1 ;
Verprolin homology domain-containing protein 1 ;
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背景:
domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain. ,function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. ,similarity:Belongs to the SCAR/WAVE family. ,similarity:Contains 1 WH2 domain. ,subcellular location:Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas. ,subunit:Component of the WAVE1 complex composed of ABI2 , CYFIP2 , C3orf10/HSPC300 , NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate , releasing activated WASF1. The complex can also be activated by NCK1 (By similarity) . Binds actin and the Arp2/3 complex. Interacts with BAIAP2. ,tissue specificity:Highly expressed in brain. Lowly expressed in testis , ovary , colon , kidney , pancreas , thymus , small intestine and peripheral blood. ,
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功能:
protein complex assembly , cell motion , cytoskeleton organization , actin filament organization , actin polymerization or depolymerization , actin filament-based process , actin cytoskeleton organization , actin filament polymerization , cellular macromolecular complex subunit organization , cellular macromolecular complex assembly , cellular protein complex assembly , macromolecular complex subunit organization , protein polymerization , macromolecular complex assembly ,protein complex biogenesis ,
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细胞定位:
Cytoplasm , cytoskeleton . Cell junction , synapse . Cell junction , focal adhesion . Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097) . Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503) . In neurons , colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity) . .
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