TH

P04177 tyrosine hydroxylase (Th) Rattus norvegicus catalytic activity:L-tyrosine + tetrahydrobiopterin + O (2) = 3 ,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. ,cofactor:Fe (2+) ion. ,enzyme regulation:Phosphorylation leads to an increase in the catalytic activity. ,function:Plays an important role in the physiology of adrenergic neurons. ,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2. ,PTM:In vitro , phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation , which results in enzyme opening and activation. ,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. ,subunit:Homotetramer. ,

regulation of neurotransmitter levels , eye development , response to hypoxia , eye photoreceptor cell differentiation ,synaptic transmission , dopaminergic , protein complex assembly , tyrosine metabolic process , cellular amino acid derivative metabolic process , biogenic amine metabolic process , catecholamine metabolic process , dopamine biosynthetic process from tyrosine , cell-cell signaling , synaptic transmission , nerve-nerve synaptic transmission ,sensory organ development , heart development , sensory perception , visual perception , behavior , learning or memory ,learning , memory , mating behavior , mating , locomotory behavior , feeding behavior , regulation of heart contraction ,aromatic amino acid family metabolic process , amine biosynthetic process , catechol metabolic process , response to endogenous stimulus , response to hormone stimulus , response to organic substance , phenol metabolic process ,reproductive behavior , transmission of nerve impulse , neuron differentiation , embryonic camera-type eye development , diol metabolic process , neurotransmitter metabolic process , neurotransmitter biosynthetic process ,cellular amino acid derivative biosynthetic process , biogenic amine biosynthetic process , epinephrine metabolic process , norepinephrine metabolic process , dopamine biosynthetic process , dopamine metabolic process , epinephrine biosynthetic process , norepinephrine biosynthetic process , catecholamine biosynthetic process , photoreceptor cell development , eye photoreceptor cell development , eating behavior , camera-type eye development , macromolecular complex subunit organization , regulation of system process , nitrogen compound biosynthetic process , response to ethanol , photoreceptor cell differentiation , embryonic eye morphogenesis , response to steroid hormone stimulus ,embryonic organ morphogenesis , embryonic organ development , eye morphogenesis , camera-type eye morphogenesis , embryonic camera-type eye morphogenesis , embryonic morphogenesis , neuron development ,neurological system process , cognition , sensory perception of light stimulus , protein oligomerization , protein homooligomerization , protein tetramerization , protein homotetramerization , behavioral interaction between organisms , oxidation reduction , macromolecular complex assembly , protein complex biogenesis , response to oxygen levels ,