TEK

Angiopoietin-1 receptor ;
Endothelial tyrosine kinase ;
Tunica interna endothelial cell kinase ;
Tyrosine kinase with Ig and EGF homology domains-2 ;
Tyrosine-protein kinase receptor TEK ;
Tyrosine-protein kinase receptor TIE-2 ;
hTIE2 ;
p140 TEK ;
CD antigen CD202b ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,disease:Defects in TEK are a cause of dominantly inherited venous malformations (VMCM) [MIM:600195]; an error of vascular morphogenesis characterized by dilated , serpiginous channels. ,function:This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation , differentiation and guides the proper patterning of endothelial cells during blood vessel formation. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains. ,similarity:Contains 3 EGF-like domains. ,similarity:Contains 3 fibronectin type-III domains. ,tissue specificity:Predominantly expressed in endothelial cells and their progenitors , the angioblasts. Has been directly found in placenta and lung , with a lower level in umbilical vein endothelial cells , brain and kidney. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell adhesion , cell-matrix adhesion , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway ,transmembrane receptor protein tyrosine kinase signaling pathway , cell-cell signaling , phosphorylation , cell-cell adhesion , biological adhesion , regulation of cell migration , cell-substrate adhesion , regulation of locomotion ,regulation of cell proliferation , regulation of angiogenesis , regulation of cell motion ,

Cell membrane ; Single-pass type I membrane protein. Cell junction . Cell junction , focal adhesion . Cytoplasm , cytoskeleton. Secreted . Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120 , PubMed:18425119) . Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells , especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244) . .