BIRC5

Baculoviral IAP repeat-containing protein 5 ;
Apoptosis inhibitor 4 ;
Apoptosis inhibitor survivin ;

domain:The BIR repeat is necessary and sufficient for HBXIP binding. ,function:May play a role in neoplasia. May counteract a default induction of apoptosis in G2/M phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7. Component of the chromosomal passenger complex (CPC) , a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. ,similarity:Belongs to the IAP family. ,similarity:Contains 1 BIR repeat. ,subcellular location:Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes. ,subunit:Homodimer. When phosphorylated , interacts with HBXIP; the resulting complex binds pro-caspase-9 , as well as active caspase-9 , but much less efficiently. Component of the CPC at least composed of BIRC5/survivin , CDCA8/borealin , INCENP and AURKB/Aurora-B. Interacts with EVI5. ,tissue specificity:Expressed only in fetal kidney and liver , and to lesser extent , lung and brain. Abundantly expressed in adenocarcinoma (lung , pancreas , colon , breast , and prostate) and in high-grade lymphomas. Also expressed in various renal cell carcinoma cell lines. ,

cell cycle checkpoint , G2/M transition of mitotic cell cycle , M phase of mitotic cell cycle , mitotic cell cycle , M phase ,nuclear division , cytokinesis , apoptosis , anti-apoptosis , cell cycle , chromosome segregation , mitosis , regulation of exit from mitosis , regulation of mitotic cell cycle , cell death , negative regulation of peptidase activity , regulation of cell cycle process , regulation of cell death , programmed cell death , death , cell cycle process , cell cycle phase , protein complex localization , positive regulation of exit from mitosis , spindle checkpoint , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , negative regulation of catalytic activity , negative regulation of caspase activity , regulation of caspase activity , negative regulation of molecular function , positive regulation of cell cycle , positive regulation of mitotic cell cycle , organelle fission ,chromosome localization , cell division , establishment of chromosome localization , interphase , interphase of mitotic cell cycle , regulation of hydrolase activity , negative regulation of hydrolase activity , organelle localization , establishment of organelle localization , regulation of cell cycle , regulation of peptidase activity , regulation of endopeptidase activity ,negative regulation of cell death ,

Cytoplasm . Nucleus . Chromosome . Chromosome , centromere . Cytoplasm , cytoskeleton , spindle . Chromosome , centromere , kinetochore . Midbody . Localizes at the centromeres from prophase to metaphase , at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB) , a XPO1/CRM1 nuclear export inhibitor (By similarity) . Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase , distributes to the midzone microtubules in anaphase and at telophase , localizes exclusively to the midbody (PubMed:11084331) . Colocalizes with AURKB at mitotic chromosomes (PubMed:14610074) . Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1-mediated nuclear export (PubMed:20826784) . .