The specific immunogen used to produce this antibody is proprietary information.

Endogenous

TRBC2

T-cell receptor beta constant 2

TRBC2 ;
T-cell receptor beta constant 2

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC) . Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell , the T cell receptor loci are rearranged and expressed in the order delta , gamma , beta , and alpha. If both delta and gamma rearrangements produce functional chains , the cell expresses delta and gamma. If not , the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable) , J (joining) , and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus , between the alpha V and J segments. During T cell development , the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains , the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity , resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq , Aug 2016] ,

Constant region of T cell receptor (TR) beta chain (PubMed:24600447) .Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC) , a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333) .Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G , CD3D , CD3E and CD247 enabling the recruitment of ZAP70. In turn , ZAP70 phosphorylates LAT , which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways , the calcium , the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways , leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462) .The T cell repertoire is generated in the thymus , by V- (D) -J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted , non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

Cell membrane .