PPARG

Peroxisome proliferator-activated receptor gamma ;
PPAR-gamma ;
Nuclear receptor subfamily 1 group C member 3 ;

alternative products:Additional isoforms seem to exist ,disease:Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance , diabetes mellitus and dyslipidemia. ,disease:Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. ,disease:Defects in PPARG may be associated with colon cancer. ,disease:Defects in PPARG may be associated with susceptibility to obesity [MIM:601665]. ,disease:Variation in PPARG is associated with carotid intimal medial thickness 1 (CIMT1) [MIM:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors. ,function:Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand , the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ,online information:Peroxisome proliferator-activated receptor entry ,online information:The Singapore human mutation and polymorphism database ,polymorphism:Genetic variation in PPARG may influence body mass index (BMI) [MIM:606641]. BMI reflects the amount of fat , lean mass , and body build. ,similarity:Belongs to the nuclear hormone receptor family. ,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily. ,similarity:Contains 1 nuclear receptor DNA-binding domain. ,subunit:Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator , leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP , leading to a mild increase in transcription of target genes. Interacts with FAM120B (By similarity) . Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with TGFB1I1. Interacts with DNTTIP2. ,tissue specificity:Highest expression in adipose tissue. Lower in skeletal muscle , spleen , heart and liver. Also detectable in placenta , lung and ovary. ,

negative regulation of transcription from RNA polymerase II promoter , regulation of cell growth , regulation of cytokine production , negative regulation of cytokine production , placenta development , immune system development ,leukocyte differentiation , myeloid leukocyte differentiation , regulation of acute inflammatory response , negative regulation of acute inflammatory response , circulatory system process , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , lipid transport , defense response , immune response , response to nutrient , blood circulation , protein localization , regulation of blood pressure , negative regulation of cell proliferation , regulation of cell size , response to temperature stimulus , response to cold , response to abiotic stimulus , response to endogenous stimulus , response to hormone stimulus , negative regulation of biosynthetic process , positive regulation of biosynthetic process , response to extracellular stimulus , response to organic substance , regulation of specific transcription from RNA polymerase II promoter , positive regulation of specific transcription from RNA polymerase II promoter , negative regulation of specific transcription from RNA polymerase II promoter , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , regulation of cellular ketone metabolic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , positive regulation of gene expression , negative regulation of gene expression , positive regulation of cell development , regulation of foam cell differentiation , negative regulation of foam cell differentiation , regulation of receptor biosynthetic process , negative regulation of receptor biosynthetic process , lipid localization , regulation of lipid storage , regulation of cholesterol storage , negative regulation of cholesterol storage , negative regulation of lipid storage , regulation of sequestering of triglyceride ,negative regulation of sequestering of triglyceride , regulation of gliogenesis , positive regulation of gliogenesis ,response to organic cyclic substance , response to purine , protein transport , monocarboxylic acid transport , organic acid transport , fatty acid transport , long-chain fatty acid transport , negative regulation of transcription , regulation of lipid metabolic process , regulation of fatty acid metabolic process , developmental maturation , hemopoiesis , myeloid cell differentiation , monocyte differentiation , negative regulation of cell growth , epithelial cell differentiation , response to caffeine , regeneration , organ regeneration , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process , negative regulation of defense response , response to nutrient levels , regulation of response to external stimulus , negative regulation of response to external stimulus , regulation of cellular component size , negative regulation of gene-specific transcription , regulation of gene-specific transcription , low-density lipoprotein receptor metabolic process , receptor biosynthetic process , response to insulin stimulus , cellular response to insulin stimulus , cellular response to hormone stimulus , response to vitamin A , response to vitamin , carbohydrate homeostasis , response to lipid , regulation of growth , regulation of cell proliferation , response to drug , homeostatic process , glucose homeostasis , lipoprotein transport , negative regulation of catalytic activity , receptor metabolic process , positive regulation of gene-specific transcription , response to alkaloid , response to peptide hormone stimulus , response to estrogen stimulus , negative regulation of molecular function , innate immune response , cell fate commitment , establishment of protein localization , fat cell differentiation , regulation of transcription , negative regulation of cell differentiation , positive regulation of cell differentiation , regulation of fat cell differentiation , positive regulation of fat cell differentiation , regulation of glial cell differentiation , positive regulation of glial cell differentiation ,low-density lipoprotein receptor biosynthetic process , negative regulation of cell size , positive regulation of lipid metabolic process , negative regulation of transcription , DNA-dependent , positive regulation of transcription , DNA-dependent , positive regulation of fatty acid metabolic process , negative regulation of growth , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , regulation of fatty acid oxidation , positive regulation of fatty acid oxidation ,carboxylic acid transport , cell maturation , hemopoietic or lymphoid organ development , response to steroid hormone stimulus , negative regulation of response to stimulus , regulation of oligodendrocyte differentiation , positive regulation of oligodendrocyte differentiation , chemical homeostasis , regulation of inflammatory response , negative regulation of inflammatory response , regulation of neurogenesis , positive regulation of neurogenesis , white fat cell differentiation ,brown fat cell differentiation , positive regulation of developmental process , negative regulation of nitrogen compound metabolic process , positive regulation of nitrogen compound metabolic process , negative regulation of multicellular organismal process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of transferase activity , negative regulation of transferase activity ,regulation of nervous system development , regulation of telomerase activity , negative regulation of telomerase activity , lipid homeostasis , response to lipoprotein stimulus , response to low density lipoprotein stimulus , regulation of cell development , epithelium development ,

Nucleus. Cytoplasm. Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.