NOS1

Nitric oxide synthase,brain ;
Constitutive NOS ;
NC-NOS ;
NOS type I ;
Neuronal NOS ;
N-NOS ;
nNOS ;
Peptidyl-cysteine S-nitrosylase NOS1 ;
bNOS ;

alternative products:Isoform 3 is produced by different alternative splicing events implicating either the untranslated exons TEX1 (TN-NOS) or TEX1B (TN-NOSB) leading to a N-terminus truncated protein which possesses enzymatic activity comparable to that of isoform 1. The C-terminal truncated isoform 4 is produced by insertion of the TEX2 exon between exons 3 and 4 of isoform 1 , leading to a frameshift and a premature stop codon ,catalytic activity:L-arginine + n NADPH + n H (+) + m O (2) = citrulline + nitric oxide + n NADP (+) . ,cofactor:Binds 1 FAD. ,cofactor:Binds 1 FMN. ,cofactor:Heme group. ,cofactor:Tetrahydrobiopterin (BH4) . May stabilize the dimeric form of the enzyme. ,disease:Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1) . IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus , leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction. ,domain:The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction , and is responsible for targeting nNos to synaptic membranes in muscles. ,enzyme regulation:Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP. ,function:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system , NO displays many properties of a neurotransmitter. ,online information:Nitric oxide synthase entry ,similarity:Belongs to the NOS family. ,similarity:Contains 1 FAD-binding FR-type domain. ,similarity:Contains 1 flavodoxin-like domain. ,similarity:Contains 1 PDZ (DHR) domain. ,subcellular location:In skeletal muscle , it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons , enriched in dendritic spines. ,subunit:Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity) . Interacts with HTR4. ,tissue specificity:Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain , also in testis , lung and kidney , and at low levels in heart , adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis , skeletal muscle , lung , and kidney , at low levels in the brain , but not in the heart and adrenal gland. ,

syncytium formation by plasma membrane fusion , regulation of neurotransmitter levels , response to hypoxia , arginine metabolic process , arginine catabolic process , nitric oxide biosynthetic process , regulation of muscle contraction ,regulation of striated muscle contraction , syncytium formation , cell-cell signaling , synaptic transmission , myoblast fusion , regulation of heart contraction , cellular amino acid catabolic process , glutamine family amino acid metabolic process , glutamine family amino acid catabolic process , response to temperature stimulus , amine catabolic process ,response to heat , response to abiotic stimulus , regulation of calcium ion transport into cytosol , negative regulation of calcium ion transport into cytosol , regulation of metal ion transport , myotube differentiation , organic acid catabolic process , transmission of nerve impulse , regulation of homeostatic process , negative regulation of homeostatic process , multicellular organismal response to stress , neurotransmitter metabolic process , neurotransmitter biosynthetic process , regulation of vasodilation , muscle cell differentiation , regulation of ion transport , negative regulation of ion transport , regulation of system process , nitrogen compound biosynthetic process , positive regulation of vasodilation , nitric oxide metabolic process , carboxylic acid catabolic process , neurological system process , negative regulation of transport , striated muscle cell differentiation , positive regulation of multicellular organismal process ,regulation of calcium ion transport , negative regulation of calcium ion transport , oxidation reduction , regulation of cardiac muscle contraction , response to oxygen levels ,

Cell membrane , sarcolemma; Peripheral membrane protein. Cell projection , dendritic spine . In skeletal muscle , it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons , enriched in dendritic spines (By similarity) . .