NFATC3

Nuclear factor of activated T-cells,cytoplasmic 3 ;
NF-ATc3 ;
NFATc3 ;
NFATx ;
T-cell transcription factor NFAT4 ;
NF-AT4 ;

domain:Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors. ,function:Plays a role in the inducible expression of cytokine genes in T-cells , especially in the induction of the IL-2. ,PTM:Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin. ,similarity:Contains 1 RHD (Rel-like) domain. ,subcellular location:Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. ,subunit:Member of the multicomponent NFATC transcription complex that consists of at least two components , a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4 , NFATC3 or members of the activating protein-1 family , MAF , GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers. ,tissue specificity:Isoform 1 is predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus , kidney , testis , spleen , prostate , ovary , small intestine , heart , placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle. ,

generation of precursor metabolites and energy , transcription , transcription , DNA-dependent , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , transcription from RNA polymerase II promoter , defense response , inflammatory response , heart development , response to wounding ,positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , energy derivation by oxidation of organic compounds , positive regulation of cellular biosynthetic process , RNA biosynthetic process , cellular respiration , regulation of transcription , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process ,

Cytoplasm . Nucleus . Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.