STEA3

Metalloreductase STEAP3 ;
Dudulin-2 ;
Six-transmembrane epithelial antigen of prostate 3 ;
Tumor suppressor-activated pathway protein 6 ;
hTSAP6 ;
pHyde ;
hpHyde ;

caution:Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033).,cofactor:FAD.,function:Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.,induction:By p53/TP53.,similarity:Belongs to the STEAP family.,similarity:Contains 1 ferric oxidoreductase domain.,subcellular location:Localizes to vesicular-like structures at the plasma membrane and around the nucleus.,subunit:Interacts with BNIP3L, MYT1 and TCTP.,tissue specificity:Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.,

transition metal ion transport, ion transport, cation transport, iron ion transport, apoptosis, cell cycle, cell death,programmed cell death, di-, tri-valent inorganic cation transport, death, metal ion transport, oxidation reduction,

Endosome membrane ; Multi-pass membrane protein . Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.