ETS1

Protein C-ets-1 ;
p54 ;

disease:ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia. ,function:Transcription factor. ,PTM:Sumoylated on Lys-15 and Lys-227 , preferentially by SUMO2; which inhibits transcriptional activity. ,PTM:Ubiquitinated; which induces proteasomal degradation. ,similarity:Belongs to the ETS family. ,similarity:Contains 1 ETS DNA-binding domain. ,similarity:Contains 1 PNT (pointed) domain. ,subunit:Interacts with MAF and MAFB (By similarity) . Binds to DAXX. Interacts with UBE2I. ,

transcription , transcription , DNA-dependent , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , transcription from RNA polymerase II promoter , induction of apoptosis , cell motion ,immune response , nucleus organization , negative regulation of cell proliferation , positive regulation of biosynthetic process , regulation of specific transcription from RNA polymerase II promoter , positive regulation of specific transcription from RNA polymerase II promoter , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , regulation of cell death ,positive regulation of cell death , induction of programmed cell death , nuclear body organization , PML body organization , positive regulation of cellular biosynthetic process , regulation of gene-specific transcription , RNA biosynthetic process , regulation of homeostatic process , regulation of cell proliferation , regulation of apoptosis ,positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death ,positive regulation of gene-specific transcription , regulation of transcription , positive regulation of cell differentiation ,regulation of myeloid cell differentiation , positive regulation of myeloid cell differentiation , regulation of erythrocyte differentiation , positive regulation of erythrocyte differentiation , negative regulation of cell cycle , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter ,response to antibiotic , cell motility , positive regulation of developmental process , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process ,regulation of cell motion , positive regulation of cell motion , localization of cell , regulation of cell cycle ,

Cytoplasm . Nucleus . Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. .