CD3 ζ (Phospho Tyr142) Cell-Based Colorimetric ELISA Kit
-KA1275C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
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CD3 ζ Rabbit pAb
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CD3 ζ (Phospho Tyr142) Rabbit pAb
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ELISA Kits
Total CD3 ζ Cell-Based Colorimetric ELISA Kit
KA4030C
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ELISA Kits
CD3 ζ (Phospho Tyr142) Cell-Based Colorimetric ELISA Kit
KA1275C
预览→
抗原&靶点信息
基因名称:
CD247
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别名:
CD247 ;
CD3Z ;
T3Z ;
TCRZ ;
T-cell surface glycoprotein CD3 zeta chain ;
T-cell receptor T3 zeta chain ;
CD antigen CD247
CD3Z ;
T3Z ;
TCRZ ;
T-cell surface glycoprotein CD3 zeta chain ;
T-cell receptor T3 zeta chain ;
CD antigen CD247
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背景:
disease:Defects in CD247 are a cause of primary T-cell immunodeficiency [MIM:610163]. Affected individuals suffer of recurrent infections. Patients T-cell counts are very low and B-cell counts are normal. ,domain:The ITAM domains mediate interaction with SHB. ,function:Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. ,online information:CD247 mutation db ,PTM:Phosphorylated on Tyr residues after T-cell receptor triggering. ,similarity:Belongs to the CD3Z/FCER1G family. ,similarity:Contains 3 ITAM domains. ,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma , delta , epsilon , zeta , and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1 Nef protein. Interacts with SHB. ,
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功能:
activation of immune response , immune response-activating cell surface receptor signaling pathway , positive regulation of immune system process , immune response-activating signal transduction , immune response-regulating signal transduction , immune response-regulating cell surface receptor signaling pathway , cell surface receptor linked signal transduction , positive regulation of response to stimulus , positive regulation of immune response , antigen receptor-mediated signaling pathway , T cell receptor signaling pathway ,
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细胞定位:
Cell membrane ; Single-pass type I membrane protein.
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信号通路
Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation
Organismal Systems >> Immune system >> Th17 cell differentiation
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
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