MAP2K6

Dual specificity mitogen-activated protein kinase kinase 6 ;
MAP kinase kinase 6 ;
MAPKK 6 ;
MAPK/ERK kinase 6 ;
MEK 6 ;
Stress-activated protein kinase kinase 3 ;
SAPK kinase 3 ;
SAPKK-3 ;
SAPKK3 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Probably activated by dual phosphorylation on Ser-207 and Thr-211.,function:Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.,induction:Strongly activated by UV, anisomycin, and osmotic shock but not by phorbol esters, NGF or EGF.,PTM:Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.,PTM:Weakly autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with Yersinia yopJ.,tissue specificity:Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.,

MAPKKK cascade, activation of MAPK activity, muscle system process, circulatory system process, heart process,protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, muscle contraction,striated muscle contraction, response to DNA damage stimulus, DNA damage induced protein phosphorylation, cell cycle, cell cycle arrest, intracellular signaling cascade, protein kinase cascade, blood circulation, regulation of cell death, positive regulation of cell death, phosphorylation, regulation of phosphate metabolic process, cell cycle process, cellular response to stress, positive regulation of kinase activity, regulation of phosphorylation, response to drug, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity, positive regulation of protein kinase activity, regulation of phosphorus metabolic process,regulation of transferase activity, positive regulation of transferase activity, heart contraction, cardiac muscle contraction,

Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Binds to microtubules.

Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas.