function:Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. ,online information:Calnexin entry ,similarity:Belongs to the calreticulin family. ,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV. ,
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功能:
protein folding , protein localization , protein secretion , protein transport , secretion by cell , establishment of protein localization , secretion ,
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细胞定位:
Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endoplasmic reticulum . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545 , PubMed:17081065) . The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232) . .