Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
-KA1267C
主要信息
Target
PRAS40 Phospho Thr246
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
PRAS40 Rabbit pAb
YT3850
预览→
Primary Antibodies
PRAS40 (Phospho Thr246) Rabbit pAb
YP0302
预览→
ELISA Kits
Total PRAS40 Cell-Based Colorimetric ELISA Kit
KA3016C
预览→
ELISA Kits
Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
KA1267C
预览→
抗原&靶点信息
基因名称:
AKT1S1 PRAS40
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蛋白名称:
Proline-rich AKT1 substrate 1;40 kDa proline-rich AKT substrate;
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别名:
AKT1S1 ;
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
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背景:
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH , MIM 113508) when phosphorylated (Kovacina et al. , 2003 [PubMed 12524439]) .[supplied by OMIM , Mar 2008] ,
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功能:
Function:May play an important role in phosphatidylinositol 3-kinase (PI3K) -AKT1 survival signaling. Substrate for AKT1 phosphorylation , but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection. ,subcellular location:Found in the cytosolic fraction of the brain. ,subunit:The phosphorylated form interacts with 14-3-3. ,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293) . ,
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细胞定位:
Cytoplasm > cytosol. Found in the cytosolic fraction of the brain.
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信号通路
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Organismal Systems >> Aging >> Longevity regulating pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
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