XIAP

E3 ubiquitin-protein ligase XIAP ;
Baculoviral IAP repeat-containing protein 4 ;
IAP-like protein ;
ILP ;
hILP ;
Inhibitor of apoptosis protein 3 ;
IAP-3 ;
hIAP-3 ;
hIAP3 ;
X-linked inhibitor of apoptosis protein ;
X-linked IAP ;

disease:Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2) [MIM:300635]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.,domain:The first BIR domain is involved in interaction with MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains.,function:Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B.,online information:XIAP mutation db,PTM:Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal degradation.,PTM:Ubiquitinated and degraded by the proteasome in apoptotic cells.,similarity:Belongs to the IAP family.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 3 BIR repeats.,subunit:Monomer, and homodimer. Interacts with SMAC and with PRSS25; these interactions inhibit apoptotic suppressor activity. Interacts with MAP3K7IP1 and AIFM1. Interaction with SMAC hinders binding of MAP3K7IP1 and AIFM1. Interacts with TCF25.,tissue specificity:Ubiquitous, except peripheral blood leukocytes.,

proteolysis, apoptosis, anti-apoptosis, response to DNA damage stimulus, cell death, macromolecule catabolic process, regulation of cell death, programmed cell death, death, modification-dependent protein catabolic process,protein catabolic process, cellular response to stress, regulation of apoptosis, negative regulation of apoptosis,regulation of programmed cell death, negative regulation of programmed cell death, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process,proteolysis involved in cellular protein catabolic process, negative regulation of cell death,

Cytoplasm. Nucleus. TLE3 promotes its nuclear localization.

Expressed in colonic crypts (at protein level) (PubMed:30389919). Ubiquitous, except peripheral blood leukocytes (PubMed:8654366).