VAV3

Guanine nucleotide exchange factor VAV3 ;
VAV-3 ;

function:Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with the PH domain of APS.,

vesicle fusion, apoptosis, induction of apoptosis, cell motion, membrane fusion, cell surface receptor linked signal transduction, integrin-mediated signaling pathway, intracellular signaling cascade, small GTPase mediated signal transduction, cell death, induction of apoptosis by extracellular signals, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, membrane organization, vesicle organization,vesicle-mediated transport, death, cell migration, regulation of lipid metabolic process, regulation of phosphate metabolic process, cell projection organization, cell projection assembly, lamellipodium assembly, regulation of cell adhesion, positive regulation of kinase activity, regulation of Rho protein signal transduction, regulation of phosphorylation, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, positive regulation of catalytic activity, regulation of GTPase activity,regulation of kinase activity, regulation of lipid kinase activity, regulation of phosphoinositide 3-kinase activity, positive regulation of phosphoinositide 3-kinase activity, positive regulation of molecular function, positive regulation of cell adhesion, positive regulation of lipid metabolic process, regulation of Ras protein signal transduction, organelle fusion,cell motility, regulation of small GTPase mediated signal transduction, regulation of phosphorus metabolic process,regulation of hydrolase activity, regulation of transferase activity, positive regulation of transferase activity,localization of cell,

Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable.