FADD (Phospho Ser194) Cell-Based Colorimetric ELISA Kit
-KA1248C
主要信息
Reactivity
Human
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
FADD Rabbit pAb
YT1656
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Primary Antibodies
FADD (Phospho Ser194) Rabbit pAb
YP0628
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ELISA Kits
Total FADD Cell-Based Colorimetric ELISA Kit
KA4094C
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ELISA Kits
FADD (Phospho Ser194) Cell-Based Colorimetric ELISA Kit
KA1248C
预览→
抗原&靶点信息
基因名称:
FADD
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别名:
Protein FADD ;
FAS-associated death domain protein ;
FAS-associating death domain-containing protein ;
Growth-inhibiting gene 3 protein ;
Mediator of receptor induced toxicity ;
FAS-associated death domain protein ;
FAS-associating death domain-containing protein ;
Growth-inhibiting gene 3 protein ;
Mediator of receptor induced toxicity ;
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背景:
domain:Contains a death domain involved in the binding of the corresponding domain within Fas receptor. ,function:Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. ,PTM:Phosphorylated. ,similarity:Contains 1 death domain. ,similarity:Contains 1 DED (death effector) domain. ,subunit:Interacts with CFLAR , PEA15 and MBD4. When phosphorylated , part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD. ,tissue specificity:Expressed in a wide variety of tissues , except for peripheral blood mononuclear leukocytes. ,
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功能:
protein complex assembly , apoptosis , induction of apoptosis , cell death , induction of apoptosis by extracellular signals ,activation of pro-apoptotic gene products , positive regulation of signal transduction , regulation of protein kinase cascade , positive regulation of cell communication , positive regulation of protein kinase cascade , regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death , death , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade , macromolecular complex subunit organization , protein oligomerization , protein heterooligomerization ,macromolecular complex assembly , necrotic cell death , protein complex biogenesis ,
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信号通路
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cell growth and death >> Apoptosis - multiple species
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway
Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway
Organismal Systems >> Immune system >> IL-17 signaling pathway
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> TNF signaling pathway
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