CBL

E3 ubiquitin-protein ligase CBL ;
Casitas B-lineage lymphoma proto-oncogene ;
Proto-oncogene c-Cbl ;
RING finger protein 55 ;
Signal transduction protein CBL ;

disease:Can be converted to an oncogenic protein by deletions or mutations that disturb its ability to down-regulate RTKs. ,domain:The N-terminus is composed of the phosphotyrosine binding (PTB) domain , a short linker region and the RING-type zinc finger. The PTB domain , which is also called TKB (tyrosine kinase binding) domain , is composed of three different subdomains: a four-helix bundle (4H) , a calcium-binding EF hand and a divergent SH2 domain. ,domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. ,function:Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase , which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes , and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases , including PDGFA , EGF and CSF1 , and terminates signaling. ,miscellaneous:This protein has one functional calcium-binding site. ,pathway:Protein modification; protein ubiquitination. ,PTM:Phosphorylated on tyrosine residues by EGFR , SYK , FYN and ZAP70 (By similarity) . Phosphorylated on tyrosine residues by INSR. ,similarity:Contains 1 CBL N-terminal domain. ,similarity:Contains 1 RING-type zinc finger. ,similarity:Contains 1 SH2 domain. ,similarity:Contains 1 UBA domain. ,similarity:Contains 2 EF-hand-like domains. ,subunit:Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA , SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR , SYK and ZAP70 via the highly conserved Cbl-N region. Also interacts with SORBS1 and INPPL1/SHIP2. Interacts with phosphorylated LAT2. May interact with CBLB. ,

proteolysis , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway ,transmembrane receptor protein tyrosine kinase signaling pathway , epidermal growth factor receptor signaling pathway , macromolecule catabolic process , protein ubiquitination , modification-dependent protein catabolic process ,regulation of endocytosis , protein catabolic process , protein modification by small protein conjugation , modification-dependent macromolecule catabolic process , cellular protein catabolic process , cellular macromolecule catabolic process , positive regulation of endocytosis , regulation of receptor-mediated endocytosis , positive regulation of receptor-mediated endocytosis , positive regulation of transport , positive regulation of cellular component organization , proteolysis involved in cellular protein catabolic process , regulation of vesicle-mediated transport ,protein modification by small protein conjugation or removal ,

Cytoplasm. Cell membrane. Cell projection , cilium . Golgi apparatus . Colocalizes with FGFR2 in lipid rafts at the cell membrane.