E2F1

Transcription factor E2F1 ;
E2F-1 ;
PBR3 ;
Retinoblastoma-associated protein 1 ;
RBAP-1 ;
Retinoblastoma-binding protein 3 ;
RBBP-3 ;
pRB-binding protein E2F-1 ;

function:Transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site , 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein , in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis. ,PTM:Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. ,similarity:Belongs to the E2F/DP family. ,subunit:Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-1 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle , RB1 becomes phosphorylated in mid-to-late G1 phase , detaches from the DRTF1/E2F complex , rendering E2F transcriptionally active. Viral oncoproteins , notably E1A , T-antigen and HPV E7 , are capable of sequestering RB protein , thus releasing the active complex. Interacts with TRRAP , which probably mediates its interaction with histone acetyltransferase complexes , leading to transcription activation. Binds TOPBP1 and EAPP. Interacts with ARID3A. ,

G1 phase of mitotic cell cycle , negative regulation of transcription from RNA polymerase II promoter , mitotic cell cycle ,transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter ,apoptosis , cell cycle , cell death , cell proliferation , negative regulation of biosynthetic process , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , positive regulation of gene expression , negative regulation of gene expression , programmed cell death , death , negative regulation of transcription , cell cycle process , cell cycle phase , forebrain development , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process , regulation of transcription , negative regulation of transcription , DNA-dependent , positive regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , negative regulation of nitrogen compound metabolic process , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process , G1 phase ,interphase , interphase of mitotic cell cycle , regulation of cell cycle ,

Nucleus .