TOB1

Protein Tob1 ;
Transducer of erbB-2 1 ;

function:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors.,PTM:Phosphorylated on Ser and Thr residues.,similarity:Belongs to the BTG family.,subunit:Interacts with CNOT7.,tissue specificity:Ubiquitous.,

protein import into nucleus, translocation, protein targeting, protein import into nucleus, intracellular protein transport,nucleocytoplasmic transport, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, SMAD protein nuclear translocation, protein localization, negative regulation of cell proliferation, negative regulation of signal transduction,negative regulation of cell communication, protein transport, protein import, regulation of ossification, regulation of BMP signaling pathway, negative regulation of BMP signaling pathway, protein localization in organelle, protein localization in nucleus, cellular protein localization, regulation of cell proliferation, establishment of protein localization,negative regulation of cell differentiation, regulation of osteoblast differentiation, negative regulation of osteoblast differentiation, intracellular transport, nuclear transport, nuclear import, cellular macromolecule localization,

Cytoplasm . Nucleus . Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. .

Ubiquitous.