CCND1

G1/S-specific cyclin-D1 ;
B-cell lymphoma 1 protein ;
BCL-1 ;
BCL-1 oncogene ;
PRAD1 oncogene ;

disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy , particularly mantle-cell lymphoma (MCL) . Translocation t (11;14) (q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle. ,disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t (11;14) (q13;q32) with the IgH locus. ,disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t (11;11) (q13;p15) with the parathyroid hormone (PTH) enhancer. ,function:Essential for the control of the cell cycle at the G1/S (start) transition. ,online information:The Singapore human mutation and polymorphism database ,PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest. ,PTM:Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex. ,similarity:Belongs to the cyclin family. ,similarity:Belongs to the cyclin family. Cyclin D subfamily. ,subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. ,

cell cycle checkpoint , DNA damage checkpoint , regulation of cyclin-dependent protein kinase activity , G1/S transition of mitotic cell cycle , mitotic cell cycle , re-entry into mitotic cell cycle , liver development , regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , reproductive developmental process ,protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , response to DNA damage stimulus , ER-nuclear signaling pathway , response to unfolded protein , cell cycle , mitotic cell cycle checkpoint ,cell surface receptor linked signal transduction , intracellular signaling cascade , regulation of mitotic cell cycle , sex differentiation , response to nutrient , positive regulation of cell proliferation , gonad development , male gonad development , response to radiation , response to UV , response to light stimulus , response to abiotic stimulus ,response to endogenous stimulus , response to hormone stimulus , negative regulation of signal transduction ,response to extracellular stimulus , response to organic substance , response to inorganic substance , response to metal ion , response to iron ion , response to X-ray , response to ionizing radiation , response to organic nitrogen ,positive regulation of phosphorus metabolic process , positive regulation of macromolecule metabolic process , negative regulation of cell communication , response to organic cyclic substance , Wnt receptor signaling pathway ,phosphorylation , regulation of phosphate metabolic process , cell cycle process , cell cycle phase , regulation of Wnt receptor signaling pathway , negative regulation of Wnt receptor signaling pathway , regulation of epithelial cell differentiation , negative regulation of epithelial cell differentiation , endoplasmic reticulum unfolded protein response ,regeneration , organ regeneration , regulation of protein modification process , positive regulation of protein modification process , DNA integrity checkpoint , G1 DNA damage checkpoint , G1/S transition checkpoint , response to nutrient levels , response to corticosteroid stimulus , response to magnesium ion , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , response to vitamin E , response to vitamin , Leydig cell differentiation , cellular response to stress , positive regulation of kinase activity , cellular response to unfolded protein , response to endoplasmic reticulum stress , cellular response to DNA damage stimulus , regulation of cell proliferation , regulation of phosphorylation , positive regulation of phosphorylation , response to drug , DNA damage response , signal transduction , positive regulation of catalytic activity , regulation of kinase activity , response to estrogen stimulus , positive regulation of molecular function , development of primary sexual characteristics , fat cell differentiation , response to ethanol , negative regulation of cell differentiation , positive regulation of cyclin-dependent protein kinase activity , positive regulation of cell cycle , regulation of protein kinase activity , positive regulation of protein kinase activity , positive regulation of phosphate metabolic process , development of primary male sexual characteristics , male sex differentiation , response to steroid hormone stimulus , reproductive structure development ,reproductive cellular process , regulation of phosphorus metabolic process , positive regulation of protein metabolic process , cell division , interphase , interphase of mitotic cell cycle , regulation of transferase activity , positive regulation of transferase activity , response to glucocorticoid stimulus , response to mineralocorticoid stimulus , response to corticosterone stimulus , response to calcium ion , regulation of cell cycle , response to protein stimulus , Wnt receptor signaling pathway through beta-catenin , response to UV-A ,

Nucleus . Cytoplasm . Nucleus membrane . Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. .