CDC6

Cell division control protein 6 homolog ;
CDC6-related protein ;
Cdc18-related protein ;
HsCdc18 ;
p62 ;
cdc6 ;
HsCDC6 ;

function:Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. ,similarity:Belongs to the CDC6/cdc18 family. ,subcellular location:The protein is nuclear in G1 and cytoplasmic in S-phase cells. ,subunit:Interacts with PCNA , ORC1L , cyclin-CDK and HUWE1. ,

cell cycle checkpoint , DNA replication checkpoint , regulation of cyclin-dependent protein kinase activity , G1 phase of mitotic cell cycle , M phase of mitotic cell cycle , mitotic cell cycle , M phase , nuclear division , DNA metabolic process , DNA replication , regulation of DNA replication , cell cycle , mitosis , traversing start control point of mitotic cell cycle , regulation of mitotic cell cycle , negative regulation of DNA replication , negative regulation of cell proliferation , negative regulation of biosynthetic process , negative regulation of macromolecule biosynthetic process , negative regulation of macromolecule metabolic process , regulation of phosphate metabolic process , cell cycle process , cell cycle phase ,regulation of DNA replication initiation , negative regulation of cellular biosynthetic process , DNA integrity checkpoint ,negative regulation of DNA replication initiation , regulation of cell proliferation , regulation of phosphorylation ,regulation of kinase activity , regulation of protein kinase activity , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , organelle fission , regulation of DNA metabolic process , negative regulation of DNA metabolic process , negative regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , cell division , G1 phase , interphase , interphase of mitotic cell cycle , regulation of transferase activity , regulation of cell cycle ,

Nucleus . Cytoplasm . The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895) . .