TAL1

T-cell acute lymphocytic leukemia protein 1 ;
TAL-1 ;
Class A basic helix-loop-helix protein 17 ;
bHLHa17 ;
Stem cell protein ;
T-cell leukemia/lymphoma protein 5 ;

alternative products:The splicing pattern is cell-lineage dependent,disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.,domain:The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.,function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.,PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.,PTM:Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.,tissue specificity:Leukemic stem cell.,

immune system development, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, cell proliferation, regulation of specific transcription from RNA polymerase II promoter, hemopoiesis, myeloid cell differentiation, erythrocyte differentiation, regulation of gene-specific transcription, regulation of homeostatic process, erythrocyte homeostasis, homeostatic process, cell fate commitment,regulation of transcription, positive regulation of cell differentiation, regulation of myeloid cell differentiation, positive regulation of myeloid cell differentiation, regulation of erythrocyte differentiation, positive regulation of erythrocyte differentiation, hemopoietic or lymphoid organ development, homeostasis of number of cells, positive regulation of developmental process, regulation of RNA metabolic process,

Nucleus .

Leukemic stem cell.