CHUK/IKBKB

catalytic activity:ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]. ,enzyme regulation:Activated when phosphorylated and inactivated when dephosphorylated. ,function:Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation , the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB , inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines. ,PTM:Phosphorylated by MAP3K14/NIK , AKT and to a lesser extent by MEKK1 , and dephosphorylated by PP2A. Autophosphorylated. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Shuttles between the cytoplasm and the nucleus. ,subunit:Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK , IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. Part of a complex composed of NCOA2 , NCOA3 , CHUK/IKKA , IKBKB , IKBKG and CREBBP. Part of a 70-90 kDa complex at least consisting of CHUK/IKKA , IKBKB , NFKBIA , RELA , IKBKAP and MAP3K14. Directly interacts with IKK-gamma/NEMO and TRPC4AP (By similarity) . May interact with TRAF2. Interacts with NALP2. May interact with MAVS/IPS1. ,tissue specificity:Widely expressed. ,

morphogenesis of an epithelium , morphogenesis of an epithelial sheet , immune system development , leukocyte differentiation , myeloid leukocyte differentiation , protein amino acid phosphorylation , phosphorus metabolic process ,phosphate metabolic process , immune response , intracellular signaling cascade , protein kinase cascade , I-kappaB kinase/NF-kappaB cascade , I-kappaB phosphorylation , phosphorylation , hemopoiesis , myeloid cell differentiation ,osteoclast differentiation , odontogenesis of dentine-containing tooth , odontogenesis , hemopoietic or lymphoid organ development , tissue morphogenesis , epithelium development ,

Cytoplasm . Nucleus . Shuttles between the cytoplasm and the nucleus.