VAV

Proto-oncogene vav

domain:The DH domain is involved in interaction with CCPG1. ,function:Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases , thus leading to cell differentiation and/or proliferation. ,miscellaneous:'Vav' stands for the sixth letter of the Hebrew alphabet. ,PTM:Phosphorylated on tyrosine residues. ,similarity:Contains 1 CH (calponin-homology) domain. ,similarity:Contains 1 DH (DBL-homology) domain. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 phorbol-ester/DAG-type zinc finger. ,similarity:Contains 1 SH2 domain. ,similarity:Contains 2 SH3 domains. ,subunit:May interact with CCPG1 (By similarity) . Interacts with APS , DOCK2 , GRB2 , GRB3 , DOCK2 , SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK , PLCG1 , GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK. ,tissue specificity:Widely expressed in hematopoietic cells but not in other cell types. ,

cell activation , endocytosis , phagocytosis , apoptosis , induction of apoptosis , immune response , cell surface receptor linked signal transduction , integrin-mediated signaling pathway , intracellular signaling cascade , cell death , induction of apoptosis by extracellular signals , membrane invagination , regulation of cell death , positive regulation of cell death ,programmed cell death , induction of programmed cell death , membrane organization , vesicle-mediated transport ,death , regulation of cell adhesion , regulation of Rho protein signal transduction , T cell activation , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of GTPase activity , leukocyte activation , positive regulation of cell adhesion , regulation of Ras protein signal transduction , lymphocyte activation , regulation of small GTPase mediated signal transduction , regulation of hydrolase activity ,