FOS

FOS ;
G0S7 ;
Proto-oncogene c-Fos ;
Cellular oncogene fos ;
G0/G1 switch regulatory protein 7

function:Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer , c-fos and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction , cell proliferation and differentiation. ,PTM:Constitutively sumoylated by SUMO1 , SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is , itself , inhibited by Ras-activated phosphorylation on Thr-232. ,PTM:Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF) . Phosphorylated , in vitro , by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232 , induced by HA-RAS , activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation. ,similarity:Belongs to the bZIP family. ,similarity:Belongs to the bZIP family. Fos subfamily. ,similarity:Contains 1 bZIP domain. ,subunit:Heterodimer with JUN. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB. ,

response to reactive oxygen species , conditioned taste aversion , response to molecule of bacterial origin , DNA metabolic process , DNA modification , DNA alkylation , DNA methylation , regulation of transcription , DNA-dependent ,regulation of transcription from RNA polymerase II promoter , one-carbon metabolic process , defense response ,inflammatory response , response to oxidative stress , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway ,transforming growth factor beta receptor signaling pathway , female pregnancy , aging , behavior , learning or memory ,learning , feeding behavior , associative learning , response to temperature stimulus , response to radiation , response to cold , response to light stimulus , response to wounding , response to mechanical stimulus , response to bacterium ,response to abiotic stimulus , response to gravity , response to toxin , response to endogenous stimulus , response to hormone stimulus , positive regulation of biosynthetic process , response to extracellular stimulus , response to organic substance , response to inorganic substance , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , response to organic cyclic substance , sleep , positive regulation of cellular biosynthetic process , cellular response to extracellular stimulus ,response to corticosteroid stimulus , methylation , response to lipopolysaccharide , response to progesterone stimulus ,cellular response to hormone stimulus , cellular response to stress , response to cytokine stimulus , cellular response to oxidative stress , cellular response to reactive oxygen species , regulation of gene expression , epigenetic , response to drug , biopolymer methylation , regulation of transcription , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , response to steroid hormone stimulus , neurological system process , cognition , positive regulation of nitrogen compound metabolic process ,regulation of RNA metabolic process , positive regulation of RNA metabolic process , response to glucocorticoid stimulus ,response to mineralocorticoid stimulus , response to corticosterone stimulus , response to cAMP , response to protein stimulus , SMAD protein signal transduction ,

Nucleus. Endoplasmic reticulum. Cytoplasm , cytosol. In quiescent cells , present in very small amounts in the cytosol. Following induction of cell growth , first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.