SPHK2

Sphingosine kinase 2 ;
SK 2 ;
SPK 2 ;

alternative products:Experimental confirmation may be lacking for some isoforms,catalytic activity:ATP + sphinganine = ADP + sphinganine 1-phosphate.,catalytic activity:ATP + sphingosine = ADP + sphingosine 1-phosphate.,cofactor:Magnesium.,function:Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine.,similarity:Contains 1 DAGKc domain.,

blood vessel development, vasculature development, membrane lipid metabolic process, phospholipid metabolic process, sphingolipid metabolic process, sphinganine metabolic process, sphinganine-1-phosphate metabolic process,sphinganine-1-phosphate biosynthetic process, sphingosine metabolic process, anti-apoptosis, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, cell proliferation, positive regulation of cell proliferation, lipid biosynthetic process, phospholipid biosynthetic process, regulation of cell death, regulation of phosphate metabolic process, organophosphate metabolic process, sphingolipid biosynthetic process, activation of protein kinase activity,positive regulation of kinase activity, regulation of cell proliferation, regulation of phosphorylation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, regulation of kinase activity, positive regulation of molecular function, nitrogen compound biosynthetic process, regulation of protein kinase activity, positive regulation of protein kinase activity, alcohol biosynthetic process, membrane lipid biosynthetic process, sphinganine biosynthetic process,sphingoid metabolic process, sphingoid biosynthetic process, regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity, negative regulation of cell death,

Cytoplasm . Nucleus . Endoplasmic reticulum . Mitochondrion inner membrane . In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656). In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132). In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547). .; [Isoform 2]: Lysosome membrane .

Mainly expressed in adult kidney, liver, and brain (PubMed:10751414). Expressed in cerebral cortex and hippocampus (at protein level) (PubMed:29615132). Isoform 1 is the predominant form expressed in most tissues (PubMed:16103110).