PTPN6

Tyrosine-protein phosphatase non-receptor type 6 ;
Hematopoietic cell protein-tyrosine phosphatase ;
Protein-tyrosine phosphatase 1C ;
PTP-1C ;
Protein-tyrosine phosphatase SHP-1 ;
SH-PTP1 ;

catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.,PTM:Phosphorylated on serine and tyrosine residues.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,similarity:Contains 2 SH2 domains.,subcellular location:In neurons, translocates into the nucleus after treatment with angiotensin II.,subunit:Monomer. Interacts with MTUS1 (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, FCRL3, FCRL4, CD300LF and CD84.,tissue specificity:Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells.,

protein amino acid dephosphorylation, phosphorus metabolic process, phosphate metabolic process, apoptosis, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, cell death, negative regulation of cell proliferation, response to wounding, programmed cell death, death, dephosphorylation, regulation of cell proliferation,

Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. .

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.