PLCG2

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 ;
Phosphoinositide phospholipase C-gamma-2 ;
Phospholipase C-IV ;
PLC-IV ;
Phospholipase C-gamma-2 ;
PLC-gamma-2 ;

catalytic activity:1-phosphatidyl-1D-myo-inositol 4 ,5-bisphosphate + H (2) O = 1D-myo-inositol 1 ,4 ,5-trisphosphate + diacylglycerol. ,cofactor:Calcium. ,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1 ,4 ,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. ,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity. ,similarity:Contains 1 C2 domain. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 PI-PLC X-box domain. ,similarity:Contains 1 PI-PLC Y-box domain. ,similarity:Contains 1 SH3 domain. ,similarity:Contains 2 SH2 domains. ,

cell activation , response to molecule of bacterial origin , activation of immune response , cell activation during immune response , lymphocyte activation during immune response , B cell activation during immune response , mature B cell differentiation during immune response , follicular B cell differentiation , mature B cell differentiation , leukocyte activation during immune response , immune response-activating cell surface receptor signaling pathway , immune system development , leukocyte differentiation , positive regulation of immune system process , immune response-activating signal transduction , immune response-regulating signal transduction , immune response-regulating cell surface receptor signaling pathway , inositol metabolic process , inositol biosynthetic process , phospholipid metabolic process , cellular ion homeostasis , cellular calcium ion homeostasis , cellular metal ion homeostasis , immune response ,cell surface receptor linked signal transduction , elevation of cytosolic calcium ion concentration , intracellular signaling cascade , phospholipid catabolic process , response to bacterium , response to organic substance , response to inorganic substance , response to metal ion , regulation of cell death , regulation of metal ion transport , lipid catabolic process , carbohydrate biosynthetic process , organophosphate metabolic process , cellular homeostasis , polyol metabolic process , regulation of transmembrane transporter activity , cellular cation homeostasis , cellular di- , tri-valent inorganic cation homeostasis , hemopoiesis , lymphocyte differentiation , B cell differentiation , response to magnesium ion , regulation of calcium ion transport via store-operated calcium channel activity , positive regulation of calcium ion transport via store-operated calcium channel activity , activation of store-operated calcium channel activity , regulation of transporter activity , positive regulation of transporter activity , regulation of ion transmembrane transporter activity ,positive regulation of ion transmembrane transporter activity , response to lipopolysaccharide , inositol trisphosphate metabolic process , inositol phosphate biosynthetic process , inositol trisphosphate biosynthetic process , response to ATP , cellular carbohydrate biosynthetic process , regulation of transmembrane transport , regulation of ion transmembrane transport , B cell activation , homeostatic process , regulation of programmed cell death , negative regulation of programmed cell death , regulation of ion transport , positive regulation of ion transport , inositol phosphate metabolic process , positive regulation of molecular function , cellular lipid catabolic process , leukocyte activation , alcohol biosynthetic process , polyol biosynthetic process , lymphocyte activation , hemopoietic or lymphoid organ development , positive regulation of response to stimulus , chemical homeostasis , positive regulation of immune response , ion homeostasis , antigen receptor-mediated signaling pathway , T cell receptor signaling pathway , positive regulation of transport , cytosolic calcium ion homeostasis , regulation of calcium ion transport , positive regulation of calcium ion transport , metal ion homeostasis , di- , tri-valent inorganic cation homeostasis , calcium ion homeostasis ,cation homeostasis , cellular chemical homeostasis , negative regulation of cell death ,