PLCG1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 ;
PLC-148 ;
Phosphoinositide phospholipase C-gamma-1 ;
Phospholipase C-II ;
PLC-II ;
Phospholipase C-gamma-1 ;
PLC-gamma-1 ;

catalytic activity:1-phosphatidyl-1D-myo-inositol 4 ,5-bisphosphate + H (2) O = 1D-myo-inositol 1 ,4 ,5-trisphosphate + diacylglycerol. ,cofactor:Calcium. ,domain:The SH3 domain mediates interaction with CLNK (By similarity) . The SH3 domain also mediates interaction with RALGPS1. ,function:PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor) -activated tyrosine kinase. ,PTM:The receptor-mediated activation of PLC-gamma-1 and PLC-gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors. ,PTM:Ubiquitinated by CBLB in activated T-cells. ,similarity:Contains 1 C2 domain. ,similarity:Contains 1 EF-hand domain. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 PI-PLC X-box domain. ,similarity:Contains 1 PI-PLC Y-box domain. ,similarity:Contains 1 SH3 domain. ,similarity:Contains 2 PH domains. ,similarity:Contains 2 SH2 domains. ,similarity:Contains 3 PH domains. ,subunit:Interacts with AGAP2 via its SH3 domain (By similarity) . Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK , VAV1 , GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and CLNK (By similarity) . Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein. ,

in utero embryonic development , phospholipid metabolic process , intracellular signaling cascade , phospholipid catabolic process , embryonic development ending in birth or egg hatching , lipid catabolic process , organophosphate metabolic process , chordate embryonic development , cellular lipid catabolic process ,

Cell projection , lamellipodium . Cell projection , ruffle . Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. .