SF1

Splicing factor 1 ;
Mammalian branch point-binding protein ;
BBP ;
mBBP ;
Transcription factor ZFM1 ;
Zinc finger gene in MEN1 locus ;
Zinc finger protein 162 ;

alternative products:Additional isoforms seem to exist,function:Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.,PTM:Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.,similarity:Belongs to the BBP/SF1 family.,similarity:Contains 1 CCHC-type zinc finger.,similarity:Contains 1 KH domain.,subunit:Binds U2AF2. Interacts with U1 snRNA. Binds EWSR1, FUS and TAF15.,tissue specificity:Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.,

spliceosome assembly, RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, nuclear mRNA 3'-splice site recognition, nuclear mRNA splicing, via spliceosome,reproductive developmental process, transcription, mRNA splice site selection, RNA processing, mRNA processing, cell cycle, sex determination, sex differentiation, negative regulation of cell proliferation, RNA splicing, gonad development,male gonad development, mRNA metabolic process, regulation of lipid metabolic process, regulation of steroid metabolic process, cell cycle process, ribonucleoprotein complex biogenesis, ribonucleoprotein complex assembly, male sex determination, Leydig cell differentiation, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, regulation of cell proliferation, macromolecular complex subunit organization,development of primary sexual characteristics, regulation of transcription, development of primary male sexual characteristics, male sex differentiation, regulation of lipid biosynthetic process, reproductive structure development,reproductive cellular process, regulation of smooth muscle cell proliferation, negative regulation of smooth muscle cell proliferation, regulation of steroid biosynthetic process, macromolecular complex assembly,

Nucleus.

Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.