LYN

Tyrosine-protein kinase Lyn ;
Lck/Yes-related novel protein tyrosine kinase ;
V-yes-1 Yamaguchi sarcoma viral related oncogene homolog ;
p53Lyn ;
p56Lyn ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH2 domain. ,similarity:Contains 1 SH3 domain. ,subunit:Interacts with phosphorylated LIME1 and with CD79A upon BCR activation. Interacts with Epstein-Barr virus LMP2A. Interacts with TGFB1I1. Interaction , via the SH2 and SH3 , domains with MUC1 is stimulated by IL7 and , the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta-catenin. Interacts with PPP1R15A via the SH3 domain. ,tissue specificity:Expressed in primary neuroblastoma tumors. ,

response to acid , cell activation , cytokine production , histamine secretion , regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , immune effector process , activation of immune response , cell activation during immune response , myeloid leukocyte activation , myeloid cell activation during immune response , histamine production during acute inflammatory response , leukocyte activation during immune response , immune response-activating cell surface receptor signaling pathway , histamine secretion during acute inflammatory response , leukocyte mediated immunity , myeloid leukocyte mediated immunity , mast cell mediated immunity , immune system development , acute inflammatory response , production of molecular mediator of acute inflammatory response , histamine secretion by mast cell , positive regulation of immune system process , immune response-activating signal transduction , immune response-regulating signal transduction , immune response-regulating cell surface receptor signaling pathway , generation of a signal involved in cell-cell signaling , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , exocytosis , defense response ,inflammatory response , immune response , response to DNA damage stimulus , response to sterol depletion , cell surface receptor linked signal transduction , intracellular signaling cascade , cell-cell signaling , protein localization ,positive regulation of cell proliferation , response to temperature stimulus , protein secretion , response to heat ,response to wounding , response to abiotic stimulus , response to toxin , response to endogenous stimulus , response to hormone stimulus , response to carbohydrate stimulus , hormone transport , positive regulation of signal transduction , response to extracellular stimulus , glial cell differentiation , response to organic substance , response to organic nitrogen , regulation of calcium ion transport into cytosol , positive regulation of phosphorus metabolic process ,positive regulation of macromolecule metabolic process , regulation of protein kinase cascade , positive regulation of cell communication , positive regulation of cell development , positive regulation of protein kinase cascade , regulation of hormone levels , regulation of metal ion transport , oligodendrocyte development , regulation of gliogenesis , positive regulation of gliogenesis , response to organic cyclic substance , response to amine stimulus , protein transport , amine transport , vesicle-mediated transport , phosphorylation , peptidyl-tyrosine phosphorylation , peptidyl-tyrosine modification , regulation of phosphate metabolic process , glial cell development , hemopoiesis , myeloid cell differentiation , erythrocyte differentiation , regulation of protein modification process , positive regulation of protein modification process , cellular response to extracellular stimulus , regulation of cellular protein metabolic process ,positive regulation of cellular protein metabolic process , regulation of homeostatic process , response to insulin stimulus , secretion by cell , cellular response to stress , erythrocyte homeostasis , cellular response to heat , gliogenesis ,regulation of cell proliferation , regulation of phosphorylation , positive regulation of phosphorylation , response to drug ,regulation of tyrosine phosphorylation of STAT protein , positive regulation of tyrosine phosphorylation of STAT protein ,homeostatic process , response to amino acid stimulus , regulation of ion transport , leukocyte degranulation , mast cell degranulation , response to peptide hormone stimulus , regulated secretory pathway , establishment of protein localization , leukocyte activation , mast cell activation , positive regulation of cell differentiation , positive regulation of phosphate metabolic process , regulation of JAK-STAT cascade , positive regulation of JAK-STAT cascade , hormone secretion , secretion , hemopoietic or lymphoid organ development , positive regulation of response to stimulus ,response to axon injury , oligodendrocyte differentiation , homeostasis of number of cells , cytokine secretion , regulation of peptidyl-tyrosine phosphorylation , positive regulation of peptidyl-tyrosine phosphorylation , regulation of neurogenesis , positive regulation of neurogenesis , positive regulation of immune response , antigen receptor-mediated signaling pathway , B cell receptor signaling pathway , positive regulation of developmental process ,regulation of phosphorus metabolic process , positive regulation of protein metabolic process , regulation of cell motion ,positive regulation of cell motion , regulation of release of sequestered calcium ion into cytosol , histamine transport ,response to protein stimulus , regulation of calcium ion transport , regulation of nervous system development ,regulation of glial cell proliferation , positive regulation of glial cell proliferation , regulation of cell development ,regulation of Fc receptor mediated stimulatory signaling pathway , positive regulation of Fc receptor mediated stimulatory signaling pathway , regulation of stress-activated protein kinase signaling pathway , positive regulation of stress-activated protein kinase signaling pathway , regulation of oligodendrocyte progenitor proliferation , positive regulation of oligodendrocyte progenitor proliferation , regulation of cellular response to stress ,

Cell membrane. Nucleus. Cytoplasm. Cytoplasm , perinuclear region. Golgi apparatus. Membrane ; Lipid-anchor . Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.