function:This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. ,PTM:Diphthamide is 2-[3-carboxyamido-3- (trimethyl-ammonio) propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A. ,PTM:Phosphorylation by EF-2 kinase completely inactivates EF-2. ,similarity:Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. ,subunit:Component of the mRNA surveillance SURF complex , at least composed of ERF1 , ERF3 (ERF3A or ERF3B) , EEF2 , UPF1/RENT1 , SMG1 , SMG8 and SMG9. ,
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