Total RFA2 Cell-Based Colorimetric ELISA Kit
-KA4267C
主要信息
Reactivity
Human, Mouse,
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
RFA2
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别名:
Replication protein A 32 kDa subunit ;
RP-A p32 ;
Replication factor A protein 2 ;
RF-A protein 2 ;
Replication protein A 34 kDa subunit ;
RP-A p34 ;
RP-A p32 ;
Replication factor A protein 2 ;
RF-A protein 2 ;
Replication protein A 34 kDa subunit ;
RP-A p34 ;
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背景:
function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.,
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功能:
nucleotide-excision repair, DNA damage removal, DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA repair, nucleotide-excision repair, nucleotide-excision repair, DNA gap filling, DNA catabolic process,response to DNA damage stimulus, macromolecule catabolic process, cellular response to stress, cellular macromolecule catabolic process,
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细胞定位:
Nucleus . Nucleus, PML body . Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. .
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