STAT4

Signal transducer and activator of transcription 4

disease:Genetic variations in STAT4 are associated with susceptibility to rheumatoid arthritis (RA) [MIM:180300]. Rheumatoid arthritis is a complex , multifactorial disorder. It is one of the most common autoimmune diseases and it is characterized by inflammation of synovial tissue and joint destruction. ,disease:Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11 (SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory , and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin , joints , kidneys , and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. ,function:Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling. ,PTM:Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity. ,similarity:Belongs to the transcription factor STAT family. ,similarity:Contains 1 SH2 domain. ,subcellular location:Translocated into the nucleus in response to phosphorylation. ,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity) . The SH2 domain interacts , in vitro , with IL12RB2 via a short cytoplasmic domain. ,

transcription , regulation of transcription , DNA-dependent , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , intracellular signaling cascade , protein kinase cascade , JAK-STAT cascade , cell proliferation , phosphorylation , cytokine-mediated signaling pathway , regulation of transcription , regulation of RNA metabolic process ,

Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.