PSMC3

26S protease regulatory subunit 6A ;
26S proteasome AAA-ATPase subunit RPT5 ;
Proteasome 26S subunit ATPase 3 ;
Proteasome subunit P50 ;
Tat-binding protein 1 ;
TBP-1 ;

function:The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). In case of HIV-1 infection, suppresses Tat-mediated transactivation.,PTM:Sumoylated by UBE2I in response to MEKK1-mediated stimuli.,similarity:Belongs to the AAA ATPase family.,subunit:May form a heterodimer with a related family member. Interacts with PAAF1. Interacts with HIV-1 Tat.,

mitotic cell cycle, in utero embryonic development, blastocyst development, proteolysis, ubiquitin-dependent protein catabolic process, cell cycle, macromolecule catabolic process, embryonic development ending in birth or egg hatching,proteasomal protein catabolic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, modification-dependent protein catabolic process, cell cycle process, protein catabolic process, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, regulation of protein ubiquitination, negative regulation of protein ubiquitination, positive regulation of protein ubiquitination, regulation of protein modification process, negative regulation of protein modification process,positive regulation of protein modification process, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, chordate embryonic development, positive regulation of catalytic activity, negative regulation of catalytic activity, proteasomal ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, negative regulation of molecular function, positive regulation of molecular function, cellular protein catabolic process, cellular macromolecule catabolic process, positive regulation of protein metabolic process, negative regulation of protein metabolic process,regulation of ligase activity, positive regulation of ligase activity, negative regulation of ligase activity, negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle, regulation of ubiquitin-protein ligase activity, regulation of ubiquitin-protein ligase activity during mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity, negative regulation of ubiquitin-protein ligase activity, proteolysis involved in cellular protein catabolic process,

Cytoplasm . Nucleus . Colocalizes with TRIM5 in the cytoplasmic bodies. .