SMAD1

Mothers against decapentaplegic homolog 1 ;
MAD homolog 1 ;
Mothers against DPP homolog 1 ;
JV4-1 ;
Mad-related protein 1 ;
SMAD family member 1 ;
SMAD 1 ;
Smad1 ;
hSMAD1 ;
Transforming growth factor-beta-signaling protein 1 ;
BSP-1 ;

function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) . ,PTM:Phosphorylated on serine by BMP type 1 receptor kinase. ,PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. ,similarity:Belongs to the dwarfin/SMAD family. ,similarity:Contains 1 MH1 (MAD homology 1) domain. ,similarity:Contains 1 MH2 (MAD homology 2) domain. ,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. ,subunit:Interacts with HGS , NANOG and ZCCHC12 (By similarity) . May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit , CREB-binding protein (CBP) , p300 , SMURF1 , SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1. ,tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle. ,

MAPKKK cascade , skeletal system development , ossification , osteoblast differentiation , urogenital system development , formation of primary germ layer , mesoderm formation , mesodermal cell fate commitment , kidney development , osteoblast fate commitment , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , RNA processing , protein complex assembly , defense response ,inflammatory response , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , transforming growth factor beta receptor signaling pathway , SMAD protein complex assembly , intracellular signaling cascade , protein kinase cascade , gamete generation , gastrulation , pattern specification process , mesoderm development , negative regulation of cell proliferation , response to wounding , response to endogenous stimulus , embryonic pattern specification ,positive regulation of biosynthetic process , response to organic substance , response to organic nitrogen , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , posttranscriptional regulation of gene expression , positive regulation of gene expression , negative regulation of gene expression , positive regulation of cell development , regulation of cell morphogenesis involved in differentiation , regulation of neuron projection development , posttranscriptional gene silencing , gene silencing , sexual reproduction , regulation of cell morphogenesis , regulation of ossification , BMP signaling pathway , midbrain development , hindbrain development , gene silencing by RNA , dsRNA fragmentation ,primary microRNA processing , positive regulation of cellular biosynthetic process , regulation of cell projection organization , positive regulation of cell projection organization , multicellular organism reproduction , ncRNA processing ,cellular macromolecular complex subunit organization , cellular macromolecular complex assembly , posttranscriptional gene silencing by RNA , gene silencing by miRNA , gene silencing by miRNA , production of miRNAs , regulation of gene expression , epigenetic , wound healing , regulation of cell proliferation , response to drug , homeostatic process ,response to dsRNA , cellular protein complex assembly , macromolecular complex subunit organization , cell fate commitment , regulation of transcription , positive regulation of cell differentiation , regulation of neuron differentiation ,regulation of osteoblast differentiation , positive regulation of osteoblast differentiation , regulation of anti-apoptosis ,positive regulation of anti-apoptosis , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , mesoderm morphogenesis , mesodermal cell differentiation , embryonic morphogenesis , reproductive process in a multicellular organism , tissue morphogenesis ,regulation of dendrite morphogenesis , regulation of neurogenesis , positive regulation of neurogenesis , regulation of dendrite development , positive regulation of dendrite morphogenesis , positive regulation of developmental process ,positive regulation of cellular component organization , positive regulation of nitrogen compound metabolic process ,regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of nervous system development , regulation of cell development , bone development , macromolecular complex assembly , protein complex biogenesis ,

Cytoplasm . Nucleus . Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271) . Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271) . Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity) . .