PRKCZ

Protein kinase C zeta type ;
nPKC-zeta ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,domain:The C1 domain does not bind the diacylglycerol (DAG) . ,domain:The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B. ,enzyme regulation:Phosphatidylinositol 3 ,4 ,5-trisphosphate might be a physiological activator. Two specific sites , Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif) , need to be phosphorylated for its full activation. ,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters , a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization. ,function:This is a calcium-independent , phospholipid-dependent , serine- and threonine-specific enzyme. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 OPR domain. ,similarity:Contains 1 phorbol-ester/DAG-type zinc finger. ,similarity:Contains 1 protein kinase domain. ,subcellular location:In the retina , localizes in the terminals of the rod bipolar cells (By similarity) . Associates with endosomes. ,subunit:Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity) . Interacts with PARD6A , PARD6B , PARD6G and SQSTM1. Part of a complex with PARD3 , PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable) . Interacts with IKBKB. ,tissue specificity:Expressed in brain , and to a lesser extent in lung , kidney and testis. ,

microtubule cytoskeleton organization , regulation of protein amino acid phosphorylation , negative regulation of protein amino acid phosphorylation , regulation of cell-matrix adhesion , positive regulation of cell-matrix adhesion ,protein complex assembly , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cellular ion homeostasis , anti-apoptosis , cytoskeleton organization , microtubule-based process , microtubule-based movement , cell surface receptor linked signal transduction , intracellular signaling cascade , behavior , learning or memory , memory , long-term memory , positive regulation of cell proliferation , negative regulation of signal transduction , regulation of phospholipase activity , positive regulation of phospholipase activity , negative regulation of phosphorus metabolic process , negative regulation of macromolecule metabolic process , positive regulation of cell communication , negative regulation of cell communication , regulation of cell-substrate adhesion , positive regulation of cell-substrate adhesion , regulation of glucose transport , positive regulation of glucose transport , regulation of cell death , microtubule-based transport , phosphorylation , peptidyl-serine phosphorylation , peptidyl-serine modification ,regulation of phosphate metabolic process , cellular homeostasis , actin filament-based process , actin cytoskeleton organization , regulation of cell adhesion , cytoskeleton-dependent intracellular transport , negative regulation of protein complex assembly , regulation of protein modification process , negative regulation of protein modification process , actin cytoskeleton reorganization , activation of phospholipase D activity , regulation of neurological system process , positive regulation of neurological system process , activation of protein kinase activity , activation of protein kinase B activity , regulation of cellular protein metabolic process , negative regulation of cellular protein metabolic process , regulation of protein localization , positive regulation of kinase activity , regulation of cell proliferation ,regulation of phosphorylation , negative regulation of phosphorylation , regulation of membrane potential , homeostatic process , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , negative regulation of catalytic activity ,regulation of protein complex assembly , regulation of kinase activity , macromolecular complex subunit organization ,regulation of system process , regulation of cellular component biogenesis , negative regulation of molecular function ,positive regulation of molecular function , positive regulation of cell adhesion , regulation of protein kinase activity ,positive regulation of protein kinase activity , negative regulation of phosphate metabolic process , regulation of glucose import , positive regulation of glucose import , regulation of insulin receptor signaling pathway , negative regulation of insulin receptor signaling pathway , intracellular transport , vesicle transport along microtubule , negative regulation of response to stimulus , chemical homeostasis , regulation of peptidyl-tyrosine phosphorylation , negative regulation of peptidyl-tyrosine phosphorylation , ion homeostasis , regulation of synaptic transmission , positive regulation of synaptic transmission , neurological system process , cognition , positive regulation of transport , negative regulation of cellular component organization , regulation of phosphorus metabolic process , positive regulation of protein transport , regulation of protein transport , positive regulation of multicellular organismal process , negative regulation of protein metabolic process , protein oligomerization , protein heterooligomerization , regulation of hydrolase activity , regulation of transferase activity , positive regulation of hydrolase activity , negative regulation of hydrolase activity , positive regulation of transferase activity , membrane depolarization , regulation of transmission of nerve impulse , positive regulation of transmission of nerve impulse , cellular chemical homeostasis , membrane hyperpolarization , regulation of lipase activity , positive regulation of lipase activity , negative regulation of cell death ,macromolecular complex assembly , regulation of establishment of protein localization , protein complex biogenesis ,

Cytoplasm . Endosome . Cell junction . Membrane ; Peripheral membrane protein . In the retina , localizes in the terminals of the rod bipolar cells (By similarity) . Associates with endosomes (PubMed:9566925) . Presence of KRIT1 , CDH5 and RAP1B is required for its localization to the cell junction (PubMed:7597083) . Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (PubMed:17313651) . Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (By similarity) . .; [Isoform 2]: Cytoplasm .