MYC BHLHE39

MYC ;
BHLHE39 ;
Myc proto-oncogene protein ;
Class E basic helix-loop-helix protein 39 ;
bHLHe39 ;
Proto-oncogene c-Myc ;
Transcription factor p64

disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t (8;12) (q24;q22) with BTG1. ,disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. ,function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. ,online information:Myc entry ,PTM:Phosphorylated by PRKDC. ,similarity:Contains 1 basic helix-loop-helix (bHLH) domain. ,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. ,

DNA catabolic process , endonucleolytic , skeletal system development , B cell apoptosis , release of cytochrome c from mitochondria , regulation of B cell apoptosis , positive regulation of B cell apoptosis , monosaccharide metabolic process ,glucose metabolic process , DNA metabolic process , DNA catabolic process , DNA fragmentation involved in apoptosis ,transcription , transcription , DNA-dependent , transcription initiation , regulation of transcription , DNA-dependent ,regulation of transcription from RNA polymerase II promoter , transcription from RNA polymerase II promoter , protein complex assembly , cellular ion homeostasis , cellular iron ion homeostasis , apoptosis , anti-apoptosis , induction of apoptosis , activation of caspase activity , cell structure disassembly during apoptosis , nucleus organization ,mitochondrion organization , cell cycle , cell cycle arrest , regulation of mitotic cell cycle , sensory organ development ,sensory perception , sensory perception of sound , cell death , cell proliferation , positive regulation of cell proliferation ,induction of apoptosis by intracellular signals , activation of pro-apoptotic gene products , negative regulation of survival gene product expression , apoptotic mitochondrial changes , macromolecule catabolic process , response to radiation , detection of external stimulus , detection of abiotic stimulus , response to mechanical stimulus , response to abiotic stimulus , positive regulation of biosynthetic process , response to organic substance , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , positive regulation of gene expression , negative regulation of gene expression ,regulation of cell death , positive regulation of cell death , positive regulation of peptidase activity , programmed cell death , induction of programmed cell death , death , protein processing , hexose metabolic process , cellular homeostasis ,cell cycle process , cellular component disassembly , cellular cation homeostasis , cellular di- , tri-valent inorganic cation homeostasis , apoptotic nuclear changes , positive regulation of cellular biosynthetic process , regulation of telomere maintenance , RNA biosynthetic process , regulation of homeostatic process , regulation of organelle organization ,regulation of chromosome organization , regulation of cell proliferation , ear morphogenesis , middle ear morphogenesis ,homeostatic process , regulation of apoptosis , positive regulation of apoptosis , negative regulation of apoptosis ,regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , response to alkaloid , positive regulation of caspase activity , regulation of caspase activity , pigmentation , ear development , macromolecular complex subunit organization ,positive regulation of molecular function , cellular macromolecule catabolic process , regulation of transcription ,regulation of survival gene product expression , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , embryonic organ morphogenesis ,embryonic organ development , embryonic morphogenesis , skeletal system morphogenesis , chemical homeostasis , ion homeostasis , neurological system process , cognition , detection of stimulus involved in sensory perception , detection of mechanical stimulus involved in sensory perception of sound , sensory perception of mechanical stimulus , detection of mechanical stimulus involved in sensory perception , detection of mechanical stimulus , regulation of DNA metabolic process , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of hydrolase activity , positive regulation of hydrolase activity , protein maturation , detection of stimulus , regulation of cell cycle , regulation of peptidase activity , regulation of endopeptidase activity , di- , tri-valent inorganic cation homeostasis , iron ion homeostasis , cation homeostasis , cellular chemical homeostasis , negative regulation of cell death , macromolecular complex assembly , lymphocyte apoptosis , regulation of lymphocyte apoptosis , positive regulation of lymphocyte apoptosis , protein complex biogenesis ,

Nucleus , nucleoplasm . Nucleus , nucleolus .