NFKBIE;IKBE

NF-kappa-B inhibitor epsilon ;
NF-kappa-BIE ;
I-kappa-B-epsilon ;
IkB-E ;
IkB-epsilon ;
IkappaBepsilon ;

function:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. ,PTM:Serine phosphorylated; followed by proteasome-dependent degradation. ,similarity:Belongs to the NF-kappa-B inhibitor family. ,similarity:Contains 6 ANK repeats. ,subunit:Interacts with RELA , REL , NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. ,tissue specificity:Highly expressed in spleen , testis and lung , followed by kidney , pancreas , heart , placenta and brain. Also expressed in granulocytes and macrophages. ,

amino acid transport , protein localization , neutral amino acid transport , amine transport , organic acid transport , serine transport , regulation of intracellular transport , negative regulation of intracellular transport , maintenance of protein location in cell , regulation of protein localization , regulation of intracellular protein transport , regulation of protein import into nucleus , negative regulation of protein import into nucleus , D-amino acid transport , D-serine transport ,regulation of transcription factor import into nucleus , negative regulation of transcription factor import into nucleus ,cytoplasmic sequestering of transcription factor , maintenance of protein location , regulation of nucleocytoplasmic transport , negative regulation of nucleocytoplasmic transport , carboxylic acid transport , negative regulation of transport , cytoplasmic sequestering of protein , regulation of protein transport , negative regulation of protein transport , maintenance of location , maintenance of location in cell , regulation of cellular localization , regulation of establishment of protein localization ,

Cytoplasm .