NFKBIB

NF-kappa-B inhibitor beta ;
NF-kappa-BIB ;
I-kappa-B-beta ;
IkB-B ;
IkB-beta ;
IkappaBbeta ;
Thyroid receptor-interacting protein 9 ;
TR-interacting protein 9 ;
TRIP-9 ;

function:Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However , the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation , explaining its slower degradation. ,PTM:Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. ,similarity:Belongs to the NF-kappa-B inhibitor family. ,similarity:Contains 6 ANK repeats. ,subunit:Interacts with THRB (via ligand-binding domain) . Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2. ,tissue specificity:Expressed in all tissues examined. ,

transcription , intracellular signaling cascade , protein kinase cascade , I-kappaB kinase/NF-kappaB cascade , cytoplasmic sequestering of NF-kappaB , protein localization , regulation of intracellular transport , negative regulation of intracellular transport , maintenance of protein location in cell , regulation of protein localization , regulation of intracellular protein transport , regulation of protein import into nucleus , negative regulation of protein import into nucleus , regulation of NF-kappaB import into nucleus , negative regulation of NF-kappaB import into nucleus , regulation of transcription factor import into nucleus , negative regulation of transcription factor import into nucleus , cytoplasmic sequestering of transcription factor , maintenance of protein location , regulation of nucleocytoplasmic transport ,negative regulation of nucleocytoplasmic transport , negative regulation of transport , cytoplasmic sequestering of protein , regulation of protein transport , negative regulation of protein transport , maintenance of location ,maintenance of location in cell , regulation of cellular localization , regulation of establishment of protein localization ,

Cytoplasm . Nucleus .