PIM1

Serine/threonine-protein kinase pim-1 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Manganese.,function:Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provide a selective advantage in tumorigenesis. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3.,induction:Strongly induced in leukocytes by the JAK/STAT pathway in response to cytokines.,PTM:Autophosphorylated on both serine/threonine and tyrosine residues.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to RP9. Isoform 2 is isolated as a monomer whereas isoform 1 complexes with other proteins. Isoform 1, but not isoform 2, binds BMX.,tissue specificity:Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.,

regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, mitotic cell cycle, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell cycle, cell proliferation,regulation of cell death, phosphorylation, regulation of phosphate metabolic process, cell cycle process, cell cycle phase, regulation of cyclin-dependent protein kinase activity during G1/S, positive regulation of cyclin-dependent protein kinase activity during G1/S, positive regulation of kinase activity, regulation of phosphorylation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, negative regulation of DNA binding, negative regulation of transcription factor activity, regulation of kinase activity, negative regulation of molecular function, positive regulation of molecular function, regulation of transcription, positive regulation of cyclin-dependent protein kinase activity,positive regulation of cell cycle, regulation of protein kinase activity, positive regulation of protein kinase activity,protein amino acid autophosphorylation, regulation of transcription factor activity, regulation of binding, negative regulation of binding, regulation of DNA binding, regulation of phosphorus metabolic process, interphase, interphase of mitotic cell cycle, regulation of transferase activity, positive regulation of transferase activity, regulation of cell cycle,negative regulation of cell death,

[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cell membrane.

Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.