PDCD4

Programmed cell death protein 4 ;
Neoplastic transformation inhibitor protein ;
Nuclear antigen H731-like ;
Protein 197/15a ;

caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Loss of expression correlated with tumor progression of lung and colon carcinoma.,domain:Binds EIF4A1 via the MA3 domains.,function:Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Inhibits the helicase activity of EIF4A and cap-dependent translation. Binds RNA.,induction:IL2 stimulation inhibits expression, while IL12 increases expression.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the PDCD4 family.,similarity:Contains 2 MI domains.,subcellular location:Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions. Exported from the nucleus in the absence of serum.,subunit:Interacts with EIF4A1 and EIF4A2.,tissue specificity:Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland.,

regulation of protein amino acid phosphorylation, negative regulation of protein kinase activity, apoptosis, aging, cell aging, cell death, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, regulation of protein kinase cascade, negative regulation of gene expression, programmed cell death, death, negative regulation of transcription, regulation of phosphate metabolic process, negative regulation of cellular biosynthetic process, regulation of protein modification process, regulation of cellular protein metabolic process, negative regulation of kinase activity, regulation of phosphorylation, negative regulation of catalytic activity, regulation of MAP kinase activity, negative regulation of MAP kinase activity, regulation of MAPKKK cascade, regulation of JUN kinase activity, negative regulation of JUN kinase activity, regulation of kinase activity, negative regulation of molecular function, regulation of transcription, negative regulation of cell cycle, regulation of protein kinase activity, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of JNK cascade, negative regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, regulation of transferase activity, negative regulation of transferase activity, regulation of cell cycle, regulation of stress-activated protein kinase signaling pathway, regulation of cellular response to stress,

Nucleus . Cytoplasm . Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). .

Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.