CASP1 IL1BC IL1BCE

CASP1 ;
IL1BC ;
IL1BCE ;
Caspase-1 ;
CASP-1 ;
Interleukin-1 beta convertase ;
IL-1BC ;
Interleukin-1 beta-converting enzyme ;
ICE ;
IL-1 beta-converting enzyme ;
p45 ;
[Cleaved into: Caspase-1 subunit p20 ;
Caspase-1 subunit p10]

alternative products:Additional isoforms seem to exist ,catalytic activity:Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-. ,enzyme regulation:Specifically inhibited by the cowpox virus Crma protein. ,function:Thiol protease that cleaves IL-1 beta between an Asp and an Ala , releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs) . Can also promote apoptosis. ,PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism. ,similarity:Belongs to the peptidase C14A family. ,similarity:Contains 1 CARD domain. ,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers , each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome , a protein complex which also includes PYCARD , CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. ,tissue specificity:Expressed in larger amounts in spleen and lung. Detected in liver , heart , small intestine , colon , thymus , prostate , skeletal muscle , peripheral blood leukocytes , kidney and testis. No expression in the brain. ,

response to hypoxia , regulation of cytokine production , positive regulation of cytokine production , proteolysis ,apoptosis , induction of apoptosis , cell death , positive regulation of signal transduction , response to organic substance , regulation of protein kinase cascade , positive regulation of cell communication , positive regulation of protein kinase cascade , regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death , death , protein processing , regulation of interleukin-1 alpha production , regulation of interleukin-1 beta production , regulation of interleukin-1 production , positive regulation of interleukin-1 alpha production , positive regulation of interleukin-1 beta production , positive regulation of interleukin-1 production ,regulation of protein localization , response to ATP , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade , regulation of interleukin-1 secretion , regulation of interleukin-1 alpha secretion , regulation of interleukin-1 beta secretion , regulation of cytokine secretion , regulation of protein secretion , positive regulation of protein secretion , positive regulation of cytokine secretion , positive regulation of interleukin-1 secretion , positive regulation of interleukin-1 alpha secretion , positive regulation of interleukin-1 beta secretion , regulation of secretion , positive regulation of secretion , positive regulation of transport , positive regulation of protein transport , regulation of protein transport , positive regulation of multicellular organismal process , protein maturation , regulation of cellular localization , regulation of establishment of protein localization , response to oxygen levels ,

Cytoplasm . Cell membrane .