OPRM1

Mu-type opioid receptor ;
M-OR-1 ;
MOR-1 ;
Mu opiate receptor ;
Mu opioid receptor ;
MOP ;
hMOP ;

function:Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.,online information:Mu opioid receptor entry,polymorphism:Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. Interacts with RGSZ17 and RGSZ20.,

regulation of nucleotide metabolic process, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, G-protein signaling, coupled to cAMP nucleotide second messenger, activation of adenylate cyclase activity by G-protein signaling pathway,activation of adenylate cyclase activity, activation of adenylate cyclase activity by dopamine receptor signaling pathway, inhibition of adenylate cyclase activity by G-protein signaling, negative regulation of adenylate cyclase activity, dopamine receptor signaling pathway, intracellular signaling cascade, sensory perception, behavior,locomotory behavior, negative regulation of cell proliferation, regulation of adenylate cyclase activity involved in G-protein signaling, positive regulation of adenylate cyclase activity by G-protein signaling pathway, second-messenger-mediated signaling, cAMP-mediated signaling, cyclic-nucleotide-mediated signaling, regulation of cyclic nucleotide metabolic process, regulation of cyclic nucleotide biosynthetic process, regulation of nucleotide biosynthetic process,regulation of cAMP metabolic process, regulation of cAMP biosynthetic process, regulation of cyclase activity, negative regulation of cyclase activity, positive regulation of cyclase activity, inhibition of adenylate cyclase activity by opioid receptor signaling pathway, regulation of cell proliferation, positive regulation of catalytic activity, negative regulation of catalytic activity, negative regulation of molecular function, positive regulation of molecular function, regulation of adenylate cyclase activity, positive regulation of adenylate cyclase activity, neurological system process, cognition,regulation of lyase activity, positive regulation of lyase activity, negative regulation of lyase activity,

Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Perikaryon . Cell projection, dendrite . Endosome . Is rapidly internalized after agonist binding. .; [Isoform 12]: Cytoplasm .

Expressed in brain. Isoform 16 and isoform 17 are detected in brain.