NR4A1

Nuclear receptor subfamily 4 group A member 1 ;
Early response protein NAK1 ;
Nuclear hormone receptor NUR/77 ;
Nur77 ;
Orphan nuclear receptor HMR ;
Orphan nuclear receptor TR3 ;
ST-59 ;
Testicular receptor 3 ;

function:Orphan nuclear receptor.,induction:By growth-stimulating agents.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with GADD45GIP1.,tissue specificity:Fetal muscle and adult liver, brain and thyroid.,

transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,induction of apoptosis, positive regulation of biosynthetic process, negative regulation of peptidase activity, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death, positive regulation of cell death, induction of programmed cell death, positive regulation of cellular biosynthetic process, regulation of apoptosis, positive regulation of apoptosis,regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of catalytic activity, negative regulation of caspase activity, regulation of caspase activity, negative regulation of molecular function, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, regulation of hydrolase activity, negative regulation of hydrolase activity, regulation of peptidase activity, regulation of endopeptidase activity,

Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). .

Fetal muscle and adult liver, brain and thyroid.