SMAD2

Mothers against decapentaplegic homolog 2 ;
MAD homolog 2 ;
Mothers against DPP homolog 2 ;
JV18-1 ;
Mad-related protein 2 ;
hMAD-2 ;
SMAD family member 2 ;
SMAD 2 ;
Smad2 ;
hSMAD2 ;

embryonic axis specification , in utero embryonic development , formation of primary germ layer , mesoderm formation ,peptide secretion , generation of a signal involved in cell-cell signaling , regionalization , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , RNA processing , protein complex assembly , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process ,cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , transforming growth factor beta receptor signaling pathway , SMAD protein complex assembly , intracellular signaling cascade , cell-cell signaling , zygotic determination of dorsal/ventral axis , gastrulation , pattern specification process , mesoderm development , heart development , negative regulation of cell proliferation , response to carbohydrate stimulus , response to hexose stimulus , response to glucose stimulus , post-embryonic development , embryonic development ending in birth or egg hatching , axis specification ,embryonic pattern specification , negative regulation of biosynthetic process , positive regulation of biosynthetic process , hormone transport , dorsal/ventral axis specification , anterior/posterior pattern formation , dorsal/ventral pattern formation , response to organic substance , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , posttranscriptional regulation of gene expression , positive regulation of gene expression , negative regulation of gene expression , regulation of epithelial to mesenchymal transition ,positive regulation of epithelial to mesenchymal transition , positive regulation of cell development , regulation of cell morphogenesis involved in differentiation , positive regulation of cell morphogenesis involved in differentiation ,regulation of hormone levels , peptide transport , phosphorylation , posttranscriptional gene silencing , gene silencing ,negative regulation of transcription , regulation of transforming growth factor beta receptor signaling pathway ,regulation of cell morphogenesis , peptide hormone secretion , insulin secretion , respiratory tube development , lung development , pancreas development , gene silencing by RNA , dsRNA fragmentation , primary microRNA processing ,negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process , regulation of gene-specific transcription , secretion by cell , response to lipid , response to monosaccharide stimulus , ncRNA processing , cellular macromolecular complex subunit organization , cellular macromolecular complex assembly ,posttranscriptional gene silencing by RNA , gene silencing by miRNA , gene silencing by miRNA , production of miRNAs ,organ growth , tube development , growth , regulation of gene expression , epigenetic , regulation of cell proliferation ,chordate embryonic development , positive regulation of gene-specific transcription , response to dsRNA , cellular protein complex assembly , macromolecular complex subunit organization , cell fate commitment , regulation of transcription , positive regulation of cell differentiation , negative regulation of transcription , DNA-dependent , positive regulation of transcription , DNA-dependent , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process ,positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , hormone secretion , secretion , mesoderm morphogenesis , paraxial mesoderm development , paraxial mesoderm morphogenesis ,embryonic morphogenesis , tissue morphogenesis , positive regulation of developmental process , regulation of binding ,positive regulation of cellular component organization , negative regulation of nitrogen compound metabolic process ,positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process , palate development , regulation of cell development , respiratory system development , macromolecular complex assembly , protein complex biogenesis ,response to cholesterol ,

Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation , migrates to the nucleus when complexed with SMAD4 (PubMed:9865696 , PubMed:21145499) . On dephosphorylation by phosphatase PPM1A , released from the SMAD2/SMAD4 complex , and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101 , PubMed:19289081) . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) . .