MRE11A

Double-strand break repair protein MRE11A ;
Meiotic recombination 11 homolog 1 ;
MRE11 homolog 1 ;
Meiotic recombination 11 homolog A ;
MRE11 homolog A ;

cofactor:Manganese.,disease:Defects in MRE11A are a cause of ataxia telangiectasia-like disorder (ATLD) [MIM:604391]. ATLD is a disease with the same clinical feature than ataxia-telangiectasia but with a somewhat milder clinical course.,disease:Defects in MRE11A may be a cause of breast cancer.,function:Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.,miscellaneous:In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.,online information:MRE11A mutation db,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MRE11/RAD32 family.,subcellular location:Localizes to discrete nuclear foci after treatment with genotoxic agents.,subunit:Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN (By similarity). Interacts with DCLRE1C/Artemis.,

regulation of DNA recombination, regulation of mitotic recombination, M phase, telomere maintenance, non-recombinational repair, DNA metabolic process, DNA replication, RNA-dependent DNA replication, DNA repair, double-strand break repair, double-strand break repair via nonhomologous end joining, DNA recombination, response to DNA damage stimulus, telomere maintenance via telomerase, cell cycle, meiosis, meiosis I, reciprocal meiotic recombination,telomere maintenance via telomere lengthening, cell cycle process, cell cycle phase, telomere organization, cellular response to stress, homeostatic process, regulation of DNA metabolic process, chromosome organization, meiotic cell cycle, M phase of meiotic cell cycle, anatomical structure homeostasis,

Nucleus . Chromosome, telomere . Chromosome . Localizes to discrete nuclear foci after treatment with genotoxic agents. .