MTOR

Serine/threonine-protein kinase mTOR ;
FK506-binding protein 12-rapamycin complex-associated protein 1 ;
FKBP12-rapamycin complex-associated protein ;
Mammalian target of rapamycin ;
mTOR ;
Mechanistic target of rapamycin ;
Rapamycin and FKBP12 target 1 ;
Rapamycin target protein 1 ;

function:Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation , and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. ,similarity:Belongs to the PI3/PI4-kinase family. ,similarity:Contains 1 FAT domain. ,similarity:Contains 1 FATC domain. ,similarity:Contains 1 PI3K/PI4K domain. ,similarity:Contains 7 HEAT repeats. ,subunit:Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1 , GBL , PRR5 , RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex. ,tissue specificity:Expressed in numerous tissues , with highest levels in testis. ,

response to acid , regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , regulation of endothelial cell proliferation , positive regulation of endothelial cell proliferation ,reproductive developmental process , regulation of glycogen biosynthetic process , regulation of carbohydrate metabolic process , regulation of translation , protein amino acid phosphorylation , phosphorus metabolic process ,phosphate metabolic process , intracellular signaling cascade , gamete generation , germ cell development , response to nutrient , regulation of actin polymerization or depolymerization , positive regulation of cell proliferation , regulation of cell size , macromolecule catabolic process , response to endogenous stimulus , response to hormone stimulus , positive regulation of biosynthetic process , regulation of catabolic process , negative regulation of catabolic process , positive regulation of signal transduction , response to extracellular stimulus , response to organic substance , response to organic nitrogen , regulation of autophagy , negative regulation of autophagy , positive regulation of macromolecule biosynthetic process , positive regulation of phosphorus metabolic process , regulation of cellular ketone metabolic process , regulation of lamellipodium assembly , positive regulation of lamellipodium assembly , positive regulation of macromolecule metabolic process , posttranscriptional regulation of gene expression , regulation of protein kinase cascade , positive regulation of organelle organization , positive regulation of cell communication , negative regulation of cell communication , regulation of cellular carbohydrate metabolic process , positive regulation of protein kinase cascade , regulation of glucose metabolic process , regulation of glucan biosynthetic process , response to amine stimulus , cell growth , regulation of macroautophagy , negative regulation of macroautophagy , phosphorylation ,peptidyl-threonine phosphorylation , peptidyl-threonine modification , regulation of lipid metabolic process , regulation of fatty acid metabolic process , regulation of phosphate metabolic process , sexual reproduction , cell projection organization , protein catabolic process , regulation of actin filament length , regulation of actin filament polymerization ,positive regulation of actin filament polymerization , positive regulation of cellular biosynthetic process , regulation of cellular catabolic process , negative regulation of cellular catabolic process , positive regulation of protein complex assembly , regulation of cell projection organization , positive regulation of cell projection organization , regulation of protein modification process , positive regulation of protein modification process , ruffle organization , response to nutrient levels , TOR signaling pathway , regulation of fatty acid beta-oxidation , regulation of response to food ,regulation of response to external stimulus , negative regulation of response to external stimulus , regulation of response to extracellular stimulus , negative regulation of response to extracellular stimulus , regulation of response to nutrient levels , negative regulation of response to nutrient levels , regulation of actin filament bundle formation ,positive regulation of actin filament bundle formation , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , regulation of protein polymerization , positive regulation of protein polymerization , regulation of Rac GTPase activity , regulation of Ras GTPase activity , regulation of Rho GTPase activity ,multicellular organism reproduction , regulation of cellular component size , response to insulin stimulus , regulation of polysaccharide metabolic process , regulation of polysaccharide biosynthetic process , regulation of actin cytoskeleton organization , regulation of actin filament-based process , regulation of organelle organization , regulation of Rac protein signal transduction , regulation of Rho protein signal transduction , growth , regulation of cell proliferation ,regulation of phosphorylation , positive regulation of phosphorylation , regulation of GTPase activity , response to amino acid stimulus , regulation of protein complex assembly , regulation of carbohydrate biosynthetic process , response to peptide hormone stimulus , regulation of generation of precursor metabolites and energy , regulation of kinase activity ,regulation of carbohydrate utilization , regulation of cellular component biogenesis , positive regulation of translation ,negative regulation of cell size , regulation of protein kinase activity , positive regulation of phosphate metabolic process , regulation of fatty acid oxidation , regulation of Ras protein signal transduction , protein amino acid autophosphorylation , negative regulation of response to stimulus , reproductive process in a multicellular organism ,reproductive cellular process , regulation of peptidyl-tyrosine phosphorylation , positive regulation of peptidyl-tyrosine phosphorylation , regulation of lipid catabolic process , regulation of small GTPase mediated signal transduction ,positive regulation of cellular component organization , regulation of phosphorus metabolic process , positive regulation of protein metabolic process , regulation of hydrolase activity , regulation of transferase activity , regulation of stress fiber formation , regulation of cytoskeleton organization , positive regulation of cytoskeleton organization , positive regulation of stress fiber formation , regulation of protein kinase B signaling cascade , positive regulation of protein kinase B signaling cascade , regulation of cell projection assembly , regulation of cellular response to stress ,

Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Cytoplasm . Nucleus , PML body . Microsome membrane . Lysosome membrane . Cytoplasmic vesicle , phagosome . Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity) . Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260 , PubMed:20381137) . Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113) . .