MDM4

Protein Mdm4 ;
Double minute 4 protein ;
Mdm2-like p53-binding protein ;
Protein Mdmx ;
p53-binding protein Mdm4 ;

alternative products:Additional isoforms seem to exist,domain:Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.,function:Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions.,mass spectrometry: PubMed:11840567,similarity:Belongs to the MDM2/MDM4 family.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SWIB domain.,subunit:Binds to p53, p73 and MDM2.,tissue specificity:In all tissues tested, with high levels in thymus.,

negative regulation of transcription from RNA polymerase II promoter, re-entry into mitotic cell cycle, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein complex assembly,apoptosis, cell cycle, cell death, cell proliferation, positive regulation of cell proliferation, negative regulation of cell proliferation, negative regulation of biosynthetic process, regulation of catabolic process, negative regulation of catabolic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, negative regulation of gene expression,programmed cell death, death, negative regulation of transcription, cell cycle process, negative regulation of cellular biosynthetic process, regulation of protein stability, regulation of cell proliferation, regulation of protein catabolic process, negative regulation of protein catabolic process, macromolecular complex subunit organization, G0 to G1 transition, regulation of transcription, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, protein stabilization, negative regulation of nitrogen compound metabolic process, negative regulation of protein metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, macromolecular complex assembly, protein complex biogenesis,

Nucleus.

Expressed in all tissues tested with high levels in thymus.