IGF1R

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,disease:Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1. ,enzyme regulation:Autophosphorylation activates the kinase activity. ,function:This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity , which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR , binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1 , with low affinity by IGF2 and not significantly activated by insulin , and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1 , IGF2 and insulin. In contrast , PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics , both bind IGF1 and have a low affinity for insulin. ,online information:IGF-1 receptor entry ,PTM:Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding. ,PTM:The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I) . ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 3 fibronectin type-III domains. ,subunit:Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain , while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR , the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. ,tissue specificity:Found as a hybrid receptor with INSR in muscle , heart , kidney , adipose tissue , skeletal muscle , hepatoma , fibrobasts , spleen and placenta (at protein level) . Expressed in a variety of tissues. ,

cell morphogenesis , cell morphogenesis involved in differentiation , reproductive developmental process , regulation of DNA replication , protein complex assembly , protein amino acid phosphorylation , phosphorus metabolic process ,phosphate metabolic process , anti-apoptosis , immune response , establishment or maintenance of cell polarity , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade , protein kinase cascade ,axonogenesis , sex determination , positive regulation of cell proliferation , insulin receptor signaling pathway , response to endogenous stimulus , response to hormone stimulus , positive regulation of biosynthetic process , response to organic substance , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , regulation of cell death , phosphoinositide 3-kinase cascade , phosphorylation , second-messenger-mediated signaling , establishment of cell polarity , cell projection organization , neuron differentiation , male sex determination , regulation of cell migration , positive regulation of cell migration , mammary gland development , neuron projection development , positive regulation of cellular biosynthetic process , response to insulin stimulus , cellular response to insulin stimulus , cellular response to hormone stimulus , cellular component morphogenesis , cell part morphogenesis , regulation of locomotion , positive regulation of locomotion , regulation of cell proliferation , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , response to peptide hormone stimulus , macromolecular complex subunit organization ,positive regulation of DNA replication , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , protein amino acid autophosphorylation , insulin-like growth factor receptor signaling pathway ,phosphoinositide-mediated signaling , neuron development , cell morphogenesis involved in neuron differentiation ,gland development , neuron projection morphogenesis , cell projection morphogenesis , regulation of DNA metabolic process , positive regulation of DNA metabolic process , positive regulation of nitrogen compound metabolic process ,protein oligomerization , protein tetramerization , regulation of cell motion , positive regulation of cell motion , protein heterooligomerization , negative regulation of cell death , macromolecular complex assembly , protein complex biogenesis ,

Cell membrane ; Single-pass type I membrane protein .